About: New nsp8 isoform suggests mechanism for tuning viral RNA synthesis

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About: New nsp8 isoform suggests mechanism for tuning viral RNA synthesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New nsp8 isoform suggests mechanism for tuning viral RNA synthesis
Creator	Li, Shuang Zhang, Yang Bartlam, Mark Rao, Zihe Zhao, Qi Li, Xuemei Zhang, Yinjie
Source	Medline; PMC
abstract	During severe acute respiratory syndrome coronavirus (SARS-CoV) infection, the activity of the replication/transcription complexes (RTC) quickly peaks at 6 hours post infection (h.p.i) and then diminishes significantly in the late post-infection stages. This “down-up-down” regulation of RNA synthesis distinguishes different viral stages: primary translation, genome replication, and finally viron assembly. Regarding the nsp8 as the primase in RNA synthesis, we confirmed that the proteolysis product of the primase (nsp8) contains the globular domain (nsp8C), and indentified the resectioning site that is notably conserved in all the three groups of coronavirus. We subsequently crystallized the complex of SARS-CoV nsp8C and nsp7, and the 3-D structure of this domain revealed its capability to interfuse into the hexadecamer super-complex. This specific proteolysis may indicate one possible mechanism by which coronaviruses to switch from viral infection to genome replication and viral assembly stages.
has issue date	2010-02-01(xsd:dateTime)
bibo:doi	10.1007/s13238-010-0028-8
bibo:pmid	21203988
has license	bronze-oa
sha1sum (hex)	c1e642c4de79eaccef82937b495299e35f473790
schema:url	https://doi.org/10.1007/s13238-010-0028-8
resource representing a document's title	New nsp8 isoform suggests mechanism for tuning viral RNA synthesis
has PubMed Central identifier	PMC4875168
has PubMed identifier	21203988
schema:publication	Protein & Cell
resource representing a document's body	covid:c1e642c4de79eaccef82937b495299e35f473790#body_text
is schema:about of	named entity 'severe acute respiratory syndrome coronavirus' named entity 'RNA' named entity 'site' named entity 'replication' named entity 'assembly' named entity 'replication' named entity 'structure' named entity 'RNA SYNTHESIS' named entity 'ACTIVITY' named entity 'CRYSTALLIZED' named entity 'CORONAVIRUSES' named entity 'ITS' named entity 'COMPLEXES' named entity '3-D' named entity 'RESECTIONING' named entity 'DOMAIN' named entity '6 HOURS' named entity 'RNA' named entity 'SPECIFIC' named entity 'RNA SYNTHESIS' named entity 'STAGES' named entity 'CONFIRMED' named entity 'CORONAVIRUS' named entity 'ASSEMBLY' named entity 'SITE' named entity 'REPLICATION' named entity 'KEYWORDS' named entity 'LATE' named entity 'ISOFORM' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'VIRON' named entity 'GLOBULAR' named entity 'AUTHORS' named entity 'VIRAL RNA' named entity 'MECHANISM' named entity 'CAPABILITY' named entity 'CONSERVED' named entity 'COMPLEX' named entity 'TRANSLATION' named entity 'GENOME' named entity 'POST' named entity 'INFECTION' named entity 'REVEALED' named entity 'PRIMASE' named entity 'SWITCH' named entity 'NEW' named entity 'VIRAL ASSEMBLY' named entity 'VIRAL LIFE CYCLE' named entity 'PROTEOLYSIS' named entity 'SUPER' named entity 'PRODUCT' named entity 'VIRAL INFECTION' named entity 'REGULATION OF RNA SYNTHESIS' named entity 'GROUPS' named entity '28H' named entity 'THESE' named entity 'POSSIBLE' named entity 'PRIMARY' named entity 'PEAKS' named entity 'WORK' named entity 'CONTAINS' named entity 'SARS-COV' named entity 'STRUCTURE' named entity 'TRANSCRIPTION' named entity 'VIRAL' named entity 'DIFFERENT' named entity 'MECHANISM' named entity 'confirmed' named entity 'domain' named entity 'crystallized' named entity 'viral life cycle' named entity 'infection' named entity 'primase' named entity 'coronaviruses' named entity 'conserved'

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