About: Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus
Creator	Li, Hui-Chun Lo, Shih-Yen Ae, Chen Hsieh, Yi-Ching Shih-Chi, A
source	Medline; PMC
abstract	Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) structural proteins (S, E, M, and NC) localize in different subcellular positions when expressed individually. However, SARS-CoV M protein is co-localized almost entirely with S, E, or NC protein when co-expressed in the cells. On the other hand, only partial co-localization was observed when S and E, S and NC, or E and NC were co-expressed in the cells. Interactions between SARS-CoV M and other structural proteins but not interactions between S and E, S and NC, or E and NC were further demonstrated by co-immunoprecipitation assay. These results indicate that SARS-CoV M protein, similar to the M proteins of other coronaviruses, plays a pivotal role in virus assembly. The cytoplasmic C-terminus domain of SARS-CoV M protein was responsible for binding to NC protein. Multiple regions of M protein interacted with E and S proteins. A model for the interactions between SARS-CoV M protein and other structural proteins is proposed. This study helps us better understand protein-protein interactions during viral assembly of SARS-CoV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11373-008-9278-3) contains supplementary material, which is available to authorized users.
has issue date	2008-09-16(xsd:dateTime)
bibo:doi	10.1007/s11373-008-9278-3
bibo:pmid	18792806
has license	no-cc
sha1sum (hex)	c24d0ef6e8b9924934b038c7d452faadf4c03869
schema:url	https://doi.org/10.1007/s11373-008-9278-3
resource representing a document's title	Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus
has PubMed Central identifier	PMC7089546
has PubMed identifier	18792806
schema:publication	J Biomed Sci
resource representing a document's body	covid:c24d0ef6e8b9924934b038c7d452faadf4c03869#body_text
is schema:about of	named entity 'VIRAL ASSEMBLY' named entity 'STRUCTURAL PROTEINS' named entity 'RESPIRATORY' named entity 'CORONAVIRUSES' named entity 'EXPRESSED' named entity 'HAND' named entity 'OBSERVED' covid:arg/c24d0ef6e8b9924934b038c7d452faadf4c03869 named entity 'ROLE' named entity 'POSITIONS' named entity 'SARS-COV' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'INTERACTIONS' named entity 'PROTEINS' named entity 'CO-LOCALIZATION' named entity 'THESE' named entity 'PROTEIN' named entity 'LOCALIZED' named entity 'BINDING' named entity 'MULTIPLE' named entity 'HELPS' named entity 'STRUCTURAL PROTEINS' named entity 'PROTEIN ' named entity 'REGIONS' named entity 'CORONAVIRUS' named entity 'STUDY' named entity 'DIFFERENT' named entity 'M PROTEIN' named entity 'RESULTS' named entity 'CELLS' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'CYTOPLASMIC' named entity 'DOMAIN' named entity 'PLAYS' named entity 'RESPONSIBLE' named entity 'BETTER' named entity 'SYNDROME' named entity 'M PROTEIN' named entity 'INTERACTIONS' named entity 'ACUTE' named entity 'ASSOCIATED' named entity 'VIRUS ASSEMBLY' named entity 'MODEL' named entity 'INTERACTED' named entity 'PROPOSED' named entity 'CO-IMMUNOPRECIPITATION ASSAY' named entity 'PARTIAL' named entity 'BUT' named entity 'CORONAVIRUS' named entity 'C-TERMINUS' named entity 'ASSOCIATED' named entity 'UNDERSTAND' named entity 'LOCALIZE' named entity '28S' named entity 'ALMOST' named entity 'PROTEIN ' named entity 'SEVERE' named entity 'SIMILAR' named entity 'SARS-CoV' named entity 'viral assembly' named entity 'virus' named entity 'co-expressed' named entity 'transfection' named entity 'transmembrane domain' named entity 'antibodies' named entity 'myc' named entity 'staining' named entity '37°C' named entity 'Vero E6' named entity 'myc' named entity 'M protein' named entity 'transfection' named entity 'cytoplasm' named entity 'immunoprecipitation' named entity 'SARS-CoV' named entity 'protein' named entity 'PBS'

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