About: Triterpene Constituents of Euphorbia Erythradenia Bioss. and their Anti-HIV Activity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Triterpene Constituents of Euphorbia Erythradenia Bioss. and their Anti-HIV Activity
Creator	Ghanadian, Mustafa Kobarfard, Farzad Memarnejadian, Arash Majid Ayatollahi, Abdul Moghadam, Mohammad Zarei, Seyed
Source	PMC
abstract	Phytochemical investigation of the aerial parts of Euphorbia erythradenia Bioss. (Euphorbiaceae), one of Iranian endemic Euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. Five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using NMR and Mass techniques. Anti HIV activity of the isolated triterpenes and ingenoid diterpenes was evaluated using single cycle replicable HIV-1 (SCR HIV-1) virions. Molecular features of the most active compound (IC(50) = 0.008 μM, CC(50) = 3.264 μM, TI = 380.64), which showed higher therapeutic index than nevirapine, was assessed using molecular docking. Docking studies demonstrated three hydrogen bonds between HIV-1 virion protease active site and this compound with a distance less than 3 A° which can be responsible for the observed anti HIV-1 activity.
has issue date	2016-01-01(xsd:dateTime)
bibo:pmid	28228800
has license	cc-by
sha1sum (hex)	c2676bad025d5a255889b8a699c86711223e3a63
resource representing a document's title	Triterpene Constituents of Euphorbia Erythradenia Bioss. and their Anti-HIV Activity
has PubMed Central identifier	PMC5242348
has PubMed identifier	28228800
schema:publication	Iran J Pharm Res
resource representing a document's body	covid:c2676bad025d5a255889b8a699c86711223e3a63#body_text
is schema:about of	named entity 'HIV-1' named entity 'active' named entity 'Triterpene' named entity 'DISTANCE' named entity 'KNOWN' named entity 'SINGLE' named entity 'IRANIAN' named entity 'HIGHER' named entity 'NEVIRAPINE' named entity 'OBSERVED' named entity 'BCM' named entity 'IDENTIFIED' named entity 'USING' named entity 'TRITERPENES' named entity 'OLEANOLIC ACID' named entity 'VIRION' named entity 'ASSESSED' named entity 'HIV' named entity 'DOCKING' named entity 'VIRIONS' named entity 'EUPHORBIA ERYTHRADENIA' named entity 'SOLVENT EXTRACTION' named entity 'MOLECULAR' named entity 'CYCLE' named entity 'PARTS' named entity 'MOLECULAR DOCKING' named entity 'PARTICULAR' named entity 'TIME' named entity 'HYDROGEN BONDS' named entity 'ENDEMIC' named entity 'RESPONSIBLE' named entity 'THEIR' named entity 'TRITERPENE' named entity 'ACTIVE SITE' named entity 'ACTIVE' named entity 'CONSTITUENTS' named entity 'ANTI-HIV ACTIVITY' named entity 'EUPHORBIA ERYTHRADENIA' named entity 'COMPOUND' named entity 'HIV-1' named entity '008' named entity 'CARRIED' named entity 'FEATURES' named entity 'LESS THAN' named entity 'NMR' named entity 'ATTENTION' named entity 'INCLUDING' named entity 'EVALUATED' named entity 'DITERPENES' named entity 'TRITERPENE' named entity 'ONE OF' named entity 'ACTIVITY' named entity 'TECHNIQUES' named entity 'MASS' named entity 'AERIAL' named entity 'PHYTOCHEMICAL' named entity 'INVESTIGATION' named entity 'EUPHORBIAS' named entity 'THERAPEUTIC INDEX' named entity '380' named entity 'PROTEASE' named entity 'CONSTITUENTS' named entity 'STUDIES' named entity 'ISOLATED' named entity 'METHANOL' covid:arg/c2676bad025d5a255889b8a699c86711223e3a63 named entity 'identified' named entity 'time' named entity 'triterpenes' named entity 'aerial' named entity 'HIV-1' named entity 'oleanolic acid' named entity 'triterpene' named entity 'HIV-1' named entity 'active compound' named entity 'nevirapine' named entity 'HIV-1' named entity 'active site'

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