About: Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1

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About: Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1
Creator	Zhou, Peng Wang, Miao Zhang, Yongguang Wang, Yonglu Lv, Jianliang Pan, Li Zhang, Zhongwang
Source	PMC
abstract	Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV). In this study, Lactobacillus plantarum strains NC8 and WCFS1 were used as oral delivery vehicles containing a pSIP411-VP1 recombinant plasmid to initiate mucosal and systemic immune responses in guinea pigs. Guinea pigs were orally vaccinated (three doses) with NC8-pSIP411, NC8-pSIP411-VP1, WCFS1-pSIP411, WCFS1-pSIP411-VP1 or milk. Animals immunized with NC8-pSIP411-VP1 and WCFS1-pSIP411-VP1 developed high levels of antigen-specific serum IgG, IgA, IgM, mucosal secretory IgA (sIgA) and neutralizing antibodies, and revealed stronger cell-mediated immune responses and enhanced protection against FMDV challenge compared with control groups. The recombinant pSIP411-VP1 effectively improved immunoprotection against FMDV in guinea pigs.
has issue date	2015-12-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0143750
bibo:pmid	26629822
has license	cc-by
sha1sum (hex)	c280d46d6fa7e2c2938a5c09bd6b092e1058a9b0
schema:url	https://doi.org/10.1371/journal.pone.0143750
resource representing a document's title	Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1
has PubMed Central identifier	PMC4667879
has PubMed identifier	26629822
schema:publication	PLoS One
resource representing a document's body	covid:c280d46d6fa7e2c2938a5c09bd6b092e1058a9b0#body_text
is schema:about of	named entity 'ORAL ADMINISTRATION' named entity 'Lactobacillus plantarum' named entity 'delivery vehicles' named entity 'IgG' named entity 'IgA' named entity 'Foot-and-Mouth Disease' named entity 'Virus' covid:arg/c280d46d6fa7e2c2938a5c09bd6b092e1058a9b0 named entity 'PROTECTION' named entity 'VACCINATED' named entity 'RECOMBINANT PLASMID' named entity 'VEHICLES' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'IGA' named entity 'RECOMBINANT' named entity 'MEDIATED' named entity 'FMDV' named entity 'LACTOBACILLUS PLANTARUM' named entity 'COMPARED' named entity 'MUCOSAL' named entity 'GUINEA PIGS' named entity 'SYSTEMIC' named entity 'LEVELS' named entity 'VP1' named entity 'SPECIFIC' named entity 'IMMUNOPROTECTION' named entity 'HIGH' named entity 'GENERATING' named entity 'ANIMALS' named entity 'STRATEGY' named entity 'INFECTIONS' named entity 'SERUM' named entity 'PROTECTION' named entity 'NEUTRALIZING ANTIBODIES' named entity 'INITIATE' named entity 'ENHANCED' named entity 'IMMUNIZED' named entity 'ORAL DELIVERY' named entity 'MUCOSAL VACCINATION' named entity 'VP1' named entity 'IGM' named entity 'USED' named entity 'STUDY' named entity 'STRAINS' named entity 'SECRETORY IGA' named entity 'GUINEA PIGS' named entity 'IGG' named entity 'MILK' named entity 'CELL' named entity 'LACTOBACILLUS PLANTARUM' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'RECOMBINANT' named entity 'IMMUNE RESPONSES' named entity 'IMPROVED' named entity 'REVEALED' named entity 'EFFECTIVE' named entity 'DOSES' named entity 'CONTAINING' named entity 'NC8' named entity 'ORALLY' named entity 'CONTROL GROUPS' named entity 'ANTIGEN' named entity 'CHALLENGE' named entity 'strains' named entity 'control groups' named entity 'VP1' named entity 'infections' named entity 'vaccination' named entity 'IgM' named entity 'systemic' named entity 'Oral' named entity 'recombinant' named entity 'antigen' named entity 'Guinea pigs' named entity 'serum'

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