About: Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2

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About: Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2
Creator	Bøtner, A Nielsen, J Fossum, C Allan, G Ellis, J Berg, M Wallgren, P Belák, K Hasslung, F Ladekjaer-Hansen, A.-S Mcneilly, F Melin, L Segall, T Timmusk, S Wattrang, E
topic	covid:c299613a3fbcfb394f5c77261fb76fd8cb3161f2#this
source	Elsevier; Medline; PMC
abstract	An experimental model using 3-day-old snatch-farrowed colostrum-deprived piglets co-infected with porcine circovirus type 2 (PCV2) and porcine parvovirus (PPV) is at present one of the best methods to study factors affecting development of postweaning multisystemic wasting syndrome (PMWS). A Swedish isolate of PCV2 (S-PCV2) retrieved in 1993 from a healthy pig has been used in this model to reproduce PMWS in pigs from Northern Ireland. This virus has been present in the Swedish pig population for at least a decade without causing any known PMWS disease problems, despite its potential pathogenicity. The reasons for this are unknown, but could be related to genetics, absence of triggers for PCV2 upregulation (infectious agent and/or management forms) within Swedish pig husbandry. In order to confirm the pathogenicity of S-PCV2, Swedish and Danish pigs were experimentally infected with this isolate according to the established model. Swedish pigs were also infected with a reference isolate of PCV2 (PCV2-1010) to compare the severity of disease caused by the two isolates in Swedish pigs. Both Danish and Swedish pigs developed PMWS after the experimental infection with S-PCV2. Antibodies to PCV2 developed later and reached lower levels in serum from pigs infected with S-PCV2 than in pigs inoculated with PCV2-1010. In general, pigs infected with S-PCV2 showed more severe clinical signs of disease than pigs infected with PCV2-1010, but pigs from all PCV2-inoculated groups displayed gross and histological lesions consistent with PMWS. All pigs inoculated with PPV, alone or in combination with PCV2, displayed interleukin-10 responses in serum while only pigs infected with PPV in combination with PCV2 showed interferon-α in serum on repeated occasions. Thus, the pathogenicity of S-PCV2 was confirmed and a role for cytokines in the etiology of PMWS was indicated.
has issue date	2005-03-20(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2004.12.011
bibo:pmid	15737473
has license	no-cc
sha1sum (hex)	c299613a3fbcfb394f5c77261fb76fd8cb3161f2
schema:url	https://doi.org/10.1016/j.vetmic.2004.12.011
resource representing a document's title	Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2
has PubMed Central identifier	PMC7117216
has PubMed identifier	15737473
schema:publication	Vet Microbiol
resource representing a document's body	covid:c299613a3fbcfb394f5c77261fb76fd8cb3161f2#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c299613a3fbcfb394f5c77261fb76fd8cb3161f2
is schema:about of	named entity 'PIGS' named entity 'combination' named entity 'infected' named entity 'infection' named entity 'disease' named entity 'levels' named entity 'retrieved' named entity 'pigs' named entity 'All' named entity '1993' named entity 'PPV' named entity 'isolate' named entity 'pigs' named entity 'Sweden' named entity 'Swedish' named entity 'type' named entity 'SWEDISH' named entity 'PPV' named entity 'ROLE' named entity 'ACCORDING' named entity 'INDICATED' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'EXPERIMENTAL INFECTION' named entity 'ISOLATE' named entity 'INTERLEUKIN-10 ' named entity 'GROSS' named entity 'GROUPS' named entity 'PORCINE PARVOVIRUS' named entity 'GENERAL' named entity 'BEST' named entity 'DAY-OLD' named entity 'COLOSTRUM' named entity 'KNOWN' named entity 'ONE OF' named entity 'PIG' named entity 'DEVELOPMENT' named entity 'RELATED' named entity 'SERUM' named entity 'PATHOGENICITY' named entity 'POTENTIAL' named entity 'METHODS' named entity 'REFERENCE' named entity 'BUT' named entity 'UPREGULATION' named entity 'WWW' named entity 'SEVERITY' named entity 'CAUSING' named entity 'LEVELS' named entity 'TO COMPARE' named entity 'MANAGEMENT' named entity 'HISTOLOGICAL' named entity 'PROBLEMS' named entity 'ISOLATE' named entity 'SWEDEN' named entity 'CAUSED BY' named entity 'STUDY' named entity 'VIRUS' named entity 'AGENT' named entity 'PRESENT' named entity 'REPEATED' named entity 'DANISH' named entity 'CYTOKINES' named entity 'DISEASE' named entity 'GENETICS' named entity 'ESTABLISHED'

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