About: Clinical Impact of Human Coronaviruses 229E and OC43 Infection in Diverse Adult Populations

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About: Clinical Impact of Human Coronaviruses 229E and OC43 Infection in Diverse Adult Populations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Impact of Human Coronaviruses 229E and OC43 Infection in Diverse Adult Populations
Creator	Falsey, Ann Shin, Jae Walsh, Edward
Source	Medline; PMC
abstract	Background. The incidence and clinical impact of coronavirus (CoV) infection in elderly persons and those with underlying cardiopulmonary disease over a long duration is not well described. We determined the incidence and clinical impact of 229E and OC43 CoV in this population during 4 consecutive winters, and compared illnesses to influenza A, respiratory syncytial virus, and human metapneumovirus. Methods. CoV 229E and OC43 were detected by reverse transcription polymerase chain reaction and serology in 4 adult populations under surveillance for acute respiratory illness during the winters of 1999–2003. Cohorts included healthy young adults, healthy elderly adults, high-risk adults with underlying cardiopulmonary disease, and a hospitalized group. Results. Three hundred ninety-eight CoV infections were identified, with annual infection rates ranging from 2.8% to 26% in prospective cohorts, and prevalence ranging from 3.3% to 11.1% in the hospitalized cohort. The incidence of infections with each strain was similar, although asymptomatic infection and viral coinfection was significantly more common with 229E than OC43 infection. Although the incidence and clinical manifestations were similar for each strain, OC43-infected subjects tended to seek more medical care, as OC43 was twice as common as 229E among the hospitalized cohort. Conclusions. CoV infections in the elderly are frequent, likely causing substantial medical disease burden.
has issue date	2013-08-06(xsd:dateTime)
bibo:doi	10.1093/infdis/jit393
bibo:pmid	23922367
has license	bronze-oa
sha1sum (hex)	c2c14ed29cac5bf3d89d9ca8ec397b77368b392a
schema:url	https://doi.org/10.1093/infdis/jit393
resource representing a document's title	Clinical Impact of Human Coronaviruses 229E and OC43 Infection in Diverse Adult Populations
has PubMed Central identifier	PMC3805243
has PubMed identifier	23922367
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:c2c14ed29cac5bf3d89d9ca8ec397b77368b392a#body_text
is schema:about of	named entity 'OC43' named entity 'human metapneumovirus' named entity 'influenza A' named entity 'OC43' named entity 'DETERMINED' named entity 'CONSECUTIVE' named entity 'DESCRIBED' named entity 'LONG DURATION' named entity 'INFLUENZA A' named entity 'ILLNESSES' named entity 'CARDIOPULMONARY DISEASE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'INFECTION' named entity 'HUMAN' named entity 'BACKGROUND' named entity '229E' named entity 'INFECTION' named entity 'DIVERSE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'PERSONS' named entity '229E' named entity 'IMPACT' named entity 'ADULT' named entity 'CLINICAL' named entity 'POPULATIONS' named entity 'CORONAVIRUSES' named entity 'WINTERS' named entity 'IMPACT' named entity 'INCIDENCE' named entity 'NOT WELL' named entity 'CLINICAL' named entity 'COMPARED' named entity 'POPULATION' named entity 'UNDERLYING' named entity 'ELDERLY' named entity 'CORONAVIRUS' covid:arg/c2c14ed29cac5bf3d89d9ca8ec397b77368b392a named entity 'influenza' named entity 'respiratory syncytial virus' named entity 'multiple comparisons' named entity 'Infection' named entity 'IgG' named entity 'American Type Culture Collection' named entity 'viruses' named entity 'coronaviruses' named entity 'asymptomatic infection' named entity 'phosphate-buffered saline' named entity 'RSV' named entity '229E' named entity 'PCR' named entity 'OC43' named entity 'infection' named entity 'hMPV' named entity 'pulmonary function' named entity 'virulence' named entity 'influenza' named entity 'Coronavirus infections' named entity 'infection' named entity 'parainfluenza virus' named entity '229E' named entity 'clinical characteristics' named entity 'parainfluenza' named entity 'tissue culture' named entity 'CoV' named entity 'virus' named entity 'nose and throat' named entity 'viruses' named entity 'serum' named entity 'RT-PCR' named entity 'AECOPD' named entity 'H3N2' named entity '229E' named entity 'asymptomatic' named entity 'follow-up' named entity 'OC43' named entity 'OC43' named entity 'severe acute respiratory syndrome' named entity 'OC43' named entity '229E'

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