About: Pre-HCT lung computed tomography as an alternative to PFT during the COVID-19 Pandemic

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About: Pre-HCT lung computed tomography as an alternative to PFT during the COVID-19 Pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pre-HCT lung computed tomography as an alternative to PFT during the COVID-19 Pandemic
Creator	Kanda, Yoshinobu Takeshita, Junko Aikawa, Tadao Akahoshi, Yu Gomyo, Ayumi Kako, Shinichi Kawamura, Masakatsu Kawamura, Shunto Kimura, Shun-Ichi Kusuda, Machiko Matsumi, Shinpei Misaki, Yukiko Nakamura, Yuhei Nakasone, Hideki Oyama-Manabe, Noriko Tamaki, Masaharu Tanihara, Aki Yoshimura, Kazuki Yoshino, Nozomu
Source	Elsevier; Medline; PMC
abstract	The pulmonary function test (PFT) is an important test for risk stratification before allogeneic transplantation (allo-HCT). However, it might be preferable to avoid PFT as much as possible in the recent era of coronavirus disease 2019 (COVID-19), because PFT requires forced expirations and might produce aerosol, increasing the risk of COVID-19 transmission. Therefore, we tried to predict normal PFT results before allo-HCT based on computed tomography (CT) findings. This study included 390 allo-HCT recipients at our center for whom lung CT images and PFT results before allo-HCT were available. Abnormal CT findings were less likely to be observed in the normal PFT group (47.0% vs 67.4%, P = 0.015), with a high negative predictive value of 92.9%. In a multivariate analysis, normal CT was significantly associated with normal PFT (odds ratio 2.47 (95% CI 1.22 – 4.97), P = 0.012). A model for predicting normal PFT was constructed based on the results of a multivariate analysis and the area under the curve of the receiver operating characteristic analysis was 0.656, which gave a sensitivity of 45.5% and a specificity of 86.0%. The relatively high specificity of the model suggested that PFT can be omitted in patients with normal CT findings before allo-HCT.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1016/j.bbmt.2020.08.025
bibo:pmid	32860909
has license	no-cc
sha1sum (hex)	c30466b9917cf734380068747ca7e2035842a432
schema:url	https://doi.org/10.1016/j.bbmt.2020.08.025
resource representing a document's title	Pre-HCT lung computed tomography as an alternative to PFT during the COVID-19 Pandemic
has PubMed Central identifier	PMC7449931
has PubMed identifier	32860909
schema:publication	Biol Blood Marrow Transplant
resource representing a document's body	covid:c30466b9917cf734380068747ca7e2035842a432#body_text
is schema:about of	named entity 'PFT' named entity 'computed tomography' named entity 'COVID-19' named entity 'Running' named entity 'risk stratification' named entity 'PFT' named entity 'vital capacity' named entity 'logistic regression' named entity 'emphysema' named entity 'pulmonary function' named entity 'Declaration of Helsinki' named entity 'CT scan' named entity 'PFT' named entity 'SARS-CoV-2' named entity 'PFT' named entity 'logistic regression' named entity 'PFT' named entity 'neutrophil' named entity 'emphysema' named entity 'Statistical Computing' named entity 'FEV1%' named entity 'CT scan' named entity 'lymphoid malignancies' named entity 'hematology' named entity 'emphysema' named entity 'comorbidity' named entity 'Jichi Medical University' named entity 'PFT' named entity 'PFT' named entity 'PFT' named entity 'PFT' named entity 'Vienna' named entity 'fever' named entity 'PFT' named entity 'emphysema' named entity 'allogeneic hematopoietic stem cell transplantation' named entity 'Austria' named entity 'COVID-19' named entity 'reference values' named entity 'high-risk' named entity 'methotrexate' named entity '8.5' named entity 'viral disease' named entity 'lymphoid malignancies' named entity 'PFT' named entity 'cyclosporin' named entity 'Fleischner Society' named entity 'Saitama' named entity 'GVHD' named entity 'prophylaxis' named entity 'PFT' named entity 'PFT' named entity 'pulmonary complications' named entity 'tacrolimus' named entity 'positive and negative predictive values' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'emphysema' named entity 'lung' named entity 'non-invasive' named entity 'PFT' named entity 'carbon monoxide' named entity 'forced expiration' named entity '1.2'

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