About: Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels()

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About: Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels() Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels()
Creator	Ji, Z Demelo-Rodríguez, P Galeano-Valle, F Cervilla-Muñoz, E De-Miguel-Diez, J Del-Toro-Cervera, J García-Fernández-Bravo, I García-García, A Ordieres-Ortega, L Parra-Virto, A Toledano-Macías, M Toledo-Samaniego, N
Source	Elsevier; Medline; PMC
abstract	AIM: An increased risk of venous thromboembolism (VTE) in patients with COVID-19 pneumonia admitted to intensive care unit (ICU) has been reported. Whether COVID-19 increases the risk of VTE in non-ICU wards remains unknown. We aimed to evaluate the burden of asymptomatic deep vein thrombosis (DVT) in COVID-19 patients with elevated D-dimer levels. METHOD: In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/mL were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). The study was approved by the Institutional Ethics Committee. RESULTS: The study comprised 156 patients (65.4% male). All but three patients received standard doses of thromboprophylaxis. Median days of hospitalization until CCUS was 9 (IQR 5–17). CCUS was positive for DVT in 23 patients (14.7%), of whom only one was proximal DVT. Seven patients (4.5%) had bilateral distal DVT. Patients with DVT had higher median D-dimer levels: 4527 (IQR 1925-9144) ng/ml vs 2050 (IQR 1428-3235) ng/ml; p < 0.001. D-dimer levels > 1570 ng/mL were associated with asymptomatic DVT (OR 9.1; CI 95% 1.1–70.1). D-dimer showed an acceptable discriminative capacity (area under the ROC curve 0.72, 95% CI 0.61–0.84). CONCLUSION: In patients admitted with COVID-19 pneumonia and elevated D-dimer levels, the incidence of asymptomatic DVT is similar to that described in other series. Higher cut-off levels for D-dimer might be necessary for the diagnosis of DVT in COVID-19 patients.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1016/j.thromres.2020.05.018
bibo:pmid	32405101
has license	no-cc
sha1sum (hex)	c320baff699445ff7b5ac77da1e526d0254909ec
schema:url	https://doi.org/10.1016/j.thromres.2020.05.018
resource representing a document's title	Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels()
has PubMed Central identifier	PMC7219400
has PubMed identifier	32405101
schema:publication	Thromb Res
resource representing a document's body	covid:c320baff699445ff7b5ac77da1e526d0254909ec#body_text
is schema:about of	named entity 'deep vein thrombosis' named entity 'patients' named entity 'COVID-19' named entity 'DEEP VEIN THROMBOSIS' named entity 'ASYMPTOMATIC' named entity 'COVID-19' named entity 'pneumonia' named entity 'burden' named entity 'levels' named entity 'evaluate' named entity 'pneumonia' named entity 'venous thromboembolism' named entity 'asymptomatic' named entity 'VTE' named entity 'deep vein thrombosis' named entity 'pneumonia' named entity 'deep vein thrombosis' named entity 'pneumonia' named entity 'DVT' named entity 'D-dimer' named entity 'COVID-19' named entity 'thrombotic' named entity 'inflammation' named entity 'malignancy' named entity 'NPV' named entity 'DVT' named entity 'Madrid' named entity 'VTE' named entity 'Netherlands' named entity 'observational study' named entity 'COVID-19' named entity 'VTE' named entity 'asymptomatic' named entity 'asymptomatic' named entity 'sensitivity, specificity' named entity 'D-dimer' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'normal distribution' named entity 'D-dimer' named entity 'contraindicated' named entity 'venous thrombosis' named entity 'atrial fibrillation' named entity 'thromboprophylaxis' named entity 'Deep vein thrombosis' named entity 'distal' named entity 'VTE' named entity 'DVT' named entity 'hypoxemia' named entity 'thrombocytopenia' named entity 'Statistical analysis' named entity 'pathologies' named entity 'bemiparin' named entity 'pregnancy' named entity 'hemostatic' named entity 'VTE' named entity 'thrombotic events' named entity 'COVID' named entity 'asymptomatic' named entity 'VTE' named entity 'D-dimer' named entity 'IBM Corp.' named entity 'pneumonia' named entity 'hemostatic' named entity 'venous thromboembolism' named entity 'DVT' named entity 'clinical signs' named entity 'DVT' named entity 'nasopharyngeal swab' named entity 'internal medicine' named entity 'pneumonia'

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