About: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians
Creator	Long, Brit Montrief, Tim Bornstein, Kasha Coye, Austin Della Porta, Alessandra Parris, Mehruba Pharm, Msc Physician, Resident Porta, Alessandra
Source	Elsevier; PMC
abstract	BACKGROUND: Acute chloroquine and hydroxychloroquine toxicity is characterized by a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias and is associated with significant morbidity and mortality. OBJECTIVE: This review describes acute chloroquine and hydroxychloroquine toxicity, outlines the complex pathophysiologic derangements, and addresses the emergency department (ED) management of this patient population. DISCUSSION: Chloroquine and hydroxychloroquine are aminoquinoline derivatives widely used in the treatment of rheumatologic diseases including systemic lupus erythematosus and rheumatoid arthritis as well as for malaria prophylaxis. In early 2020, anecdotal reports and preliminary data suggested utility of hydroxychloroquine in attenuating viral loads and symptoms in patients with SARS-CoV-2 infection. Aminoquinoline drugs pose unique and significant toxicological risks, both during their intended use as well as in unsupervised settings by laypersons. The therapeutic range for chloroquine is narrow. Acute severe toxicity is associated with 10–30% mortality owing to a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias. Treatment in the ED is focused on decontamination, stabilization of cardiac dysrhythmias, hemodynamic support, electrolyte correction, and seizure prevention. CONCLUSIONS: An understanding of the pathophysiology of acute chloroquine and hydroxychloroquine toxicity and available emergency treatments can assist emergency clinicians in reducing the immediate morbidity and mortality associated with this disease.
has issue date	2020-07-19(xsd:dateTime)
bibo:doi	10.1016/j.ajem.2020.07.030
has license	no-cc
sha1sum (hex)	c36cce952b86fa400afb49df97c1f72407f5f8d6
schema:url	https://doi.org/10.1016/j.ajem.2020.07.030
resource representing a document's title	Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians
has PubMed Central identifier	PMC7369162
schema:publication	Am J Emerg Med
resource representing a document's body	covid:c36cce952b86fa400afb49df97c1f72407f5f8d6#body_text
is schema:about of	named entity 'chloroquine' named entity 'Journal' named entity 'pose' named entity 'toxicity' named entity 'data' named entity 'mortality' named entity 'attenuating' named entity 'toxicological' named entity 'population' named entity 'Chloroquine' named entity 'clinicians' named entity 'Acute' named entity 'RHEUMATOLOGIC' named entity 'REPORTS' named entity 'EARLY' named entity 'REVIEW' named entity 'PRE' named entity 'ACUTE' covid:arg/c36cce952b86fa400afb49df97c1f72407f5f8d6 named entity 'addresses' named entity 'unique' named entity 'Discussion' named entity 'anecdotal reports' named entity 'rheumatoid arthritis' named entity 'This' named entity 'risks' named entity 'hydroxychloroquine' named entity 'rheumatoid arthritis' named entity 'SARS-CoV-2' named entity 'infection' named entity 'hydroxychloroquine' named entity 'emergency department' named entity 'hydroxychloroquine' named entity 'dysrhythmias' named entity 'Hydroxychloroquine' named entity 'toxicity' named entity 'outlines' named entity 'meclizine' named entity 'case reports' named entity 'aminoquinolines' named entity 'poison control centers' named entity 'nausea' named entity 'potassium chloride' named entity 'bronchial epithelial cells' named entity 'depigmentation' named entity 'SARS-CoV-2' named entity 'hydroxychloroquine' named entity 'infection' named entity 'plasma levels' named entity 'myopathy' named entity 'depression' named entity 'P450' named entity 'diazepam' named entity 'benzodiazepine' named entity 'antiviral activity' named entity 'Primaquine' named entity 'metabolism' named entity 'atrioventricular junction' named entity 'ventricular arrhythmias' named entity 'COVID' named entity 'diarrhea' named entity 'Chloroquine' named entity 'chloroquine' named entity 'COVID' named entity 'class of drugs' named entity 'toxicity' named entity 'Potassium' named entity 'diastolic' named entity 'phospholipid' named entity 'June 2020' named entity 'serum' named entity 'renally' named entity 'potassium channels' named entity 'electrolyte' named entity 'sodium'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software