About: Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis

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About: Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis
Creator	Hwang, Mihyun Min, Booki Hinton, David Phares, Timothy Stohlman, Stephen Berg-Mann, Cornelia
source	Medline; PMC
abstract	CD4 T-cell help is not a universal requirement for effective primary CD8 T cells but is essential to generate memory CD8 T cells capable of recall responses. This study examined how CD4 T cells affect primary and secondary anti-viral CD8 T-cell responses within the central nervous system (CNS) during encephalomyelitis induced by sublethal gliatropic coronavirus. CD4 T-cell depletion before infection did not impair peripheral expansion, interferon-γ production, CNS recruitment or initial CNS effector capacity of virus-specific CD8 T cells ex vivo. Nevertheless, impaired virus control in the absence of CD4 T cells was associated with gradually diminished CNS CD8 T-cell interferon-γ production. Furthermore, within the CD8 T-cell population short-lived effector cells were increased and memory precursor effector cells were significantly decreased, consistent with higher T-cell turnover. Transfer of memory CD8 T cells to reduce viral load in CD4-depleted mice reverted the recipient CNS CD8 T-cell phenotype to that in wild-type control mice. However, memory CD8 T cells primed without CD4 T cells and transferred into infected CD4-sufficient recipients expanded less efficiently and were not sustained in the CNS, contrasting with their helped counterparts. These data suggest that CD4 T cells are dispensable for initial expansion, CNS recruitment and differentiation of primary resident memory CD8 T cells as long as the duration of antigen exposure is limited. By contrast, CD4 T cells are essential to prolong primary CD8 T-cell function in the CNS and imprint memory CD8 T cells for recall responses.
has issue date	2015-02-13(xsd:dateTime)
bibo:doi	10.1111/imm.12378
bibo:pmid	25187405
has license	bronze-oa
sha1sum (hex)	c388db3e01b02560b714c3f8da9f807ab6173a15
schema:url	https://doi.org/10.1111/imm.12378
resource representing a document's title	Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis
has PubMed Central identifier	PMC4557674
has PubMed identifier	25187405
schema:publication	Immunology
resource representing a document's body	covid:c388db3e01b02560b714c3f8da9f807ab6173a15#body_text
is schema:about of	named entity 'memory' named entity 'expanded' named entity 'imprint' named entity 'effector' named entity 'CD4' named entity 'T-cell' named entity 'CD8' named entity 'effector cells' named entity 'CD8' named entity 'effector cells' named entity 'contrasting' named entity 'production' named entity 'essential' named entity 'CD8' named entity 'CD4' named entity 'primary' named entity 'data' named entity 'function' named entity 'viral load' named entity 'virus' named entity 'phenotype' named entity 'CNS' named entity 'T-cell' named entity 'CNS' named entity 'CD4 T cells' named entity 'CD4 T-cell' named entity 'CNS' named entity 'CD4 T cells' named entity 'CD8 T-cell' named entity 'CD8 T cells' named entity 'CD8 T-cell' named entity 'CD8 T-cell' named entity 'CD4 T-cell' named entity 'TRAIL' named entity 'CD4 T-cell' named entity 'statistical significance' named entity 'CD8 T cells' named entity 'statistically significant' named entity 'antigen' named entity 'CD127' named entity 'SLEC' named entity 'CD8' named entity 'Applied Biosystems' named entity 'CD4' named entity 'virus' named entity 'paralysis' named entity 'CD8 T cells' named entity 'apoptotic' named entity 'memory T cells' named entity 'virus replication' named entity 'viral load' named entity 'CD8 T-cell' named entity 'rat' named entity 'macrophages' named entity 'IFN' named entity 'cytokine' named entity 'mAb' named entity 'microglia' named entity 'antigen' named entity 'microglia' named entity 'T-cell' named entity 'splenic' named entity 'Virus' named entity 'CD8 T cells' named entity 'anti-viral' named entity 'effector cells' named entity 'CD127' named entity 'CD8' named entity 'CD4 T cells' named entity 'CD8 T cells' named entity 'CD4' named entity 'CLN' named entity 'Tcell' named entity 'virus' named entity 'CD4 T cells' named entity 'CD40'

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