About: A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway

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About: A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway
Creator	Ludwig, Stephan Ehrhardt, Christina
Source	Medline; PMC
abstract	Upon influenza A virus infection of cells, a wide variety of antiviral and virus‐supportive signalling pathways are induced. Phosphatidylinositol‐3‐kinase (PI3K) is a recent addition to the growing list of signalling mediators that are activated by these viruses. Several studies have addressed the role of PI3K and the downstream effector protein kinase Akt in influenza A virus‐infected cells. PI3K/Akt signalling is activated by diverse mechanisms in a biphasic manner and is required for multiple functions during infection. While the kinase supports activation of the interferon regulatory factor‐3 during antiviral interferon induction, it also exhibits virus supportive functions. In fact, PI3K not only regulates a very early step during viral entry but also results in suppression of premature apoptosis at later stages of infection. The latter function is dependent on the expression of the viral non‐structural protein‐1 (A/NS1). It has been shown that PI3K activation occurs by direct interaction of A/NS1 with the p85 regulatory subunit and interaction sites of A/NS1 and p85 have now been mapped in detail. Here, we summarize the current knowledge on influenza virus‐induced PI3K signalling and how this pathway supports viral propagation.
has issue date	2009-03-12(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2009.01309.x
bibo:pmid	19290913
has license	no-cc
sha1sum (hex)	c3face504f0138ed902de522d63f53a713a12eae
schema:url	https://doi.org/10.1111/j.1462-5822.2009.01309.x
resource representing a document's title	A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway
has PubMed Central identifier	PMC7162392
has PubMed identifier	19290913
schema:publication	Cell Microbiol
resource representing a document's body	covid:c3face504f0138ed902de522d63f53a713a12eae#body_text
is schema:about of	named entity 'PI3K' named entity 'SIGNALLING' named entity 'HERE' named entity 'current' named entity 'PI3K' named entity 'subunit' named entity 'supports' named entity 'Akt' named entity 'PI3K signalling' named entity 'influenza viruses' named entity 'NS1' named entity 'influenza B virus' named entity 'SH2' named entity 'PI3K inhibitor' named entity 'C-terminus' named entity 'NS5A' named entity 'nuclear export' named entity 'GSK-3b' named entity 'murine' named entity 'recombinant virus' named entity 'cell signalling' named entity 'infection' named entity 'kinase' named entity 'NF-kB' named entity 'transcription factor' named entity 'protein' named entity 'Akt' named entity 'phosphorylate' named entity 'binding protein' named entity 'p85a' named entity 'Apoptosis' named entity 'phosphatase' named entity 'CrkL' named entity 'SH3' named entity 'RIG-I' named entity 'virus' named entity 'homologue' named entity 'mammals' named entity 'early endosomes' named entity 'protein' named entity 'genus' named entity 'Akt' named entity 'non-structural protein' named entity 'apoptosis' named entity 'PI3K' named entity 'influenza virus' named entity 'NS1' named entity 'binding domain' named entity 'vesicular transport' named entity 'antiviral' named entity 'TGF-b' named entity 'Akt' named entity 'PI3K' named entity 'PI3K' named entity 'PI3K/Akt signalling' named entity 'protein' named entity 'rapamycin-insensitive companion of mTOR' named entity 'mTORC1' named entity 'poliovirus' named entity 'Valine' named entity 'PI3K' named entity 'PTEN' named entity 'viruses' named entity 'Flaviviridae' named entity 'influenza' named entity 'single-stranded RNA' named entity 'splicing' named entity 'IRF-3' named entity 'phosphatidylinositol-3,4,5-triphosphate' named entity 'virus replication' named entity 'Orthomyxoviridae' named entity 'protein' named entity 'chronic infection' named entity 'double minute' named entity 'anti-apoptotic' named entity 'defence mechanisms' named entity 'virus' named entity 'RNPs' named entity 'tyrosine' named entity 'phosphorylation'

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