About: Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infection Using Real-time RT-PCR in a Hospital in Northern Taiwan

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About: Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infection Using Real-time RT-PCR in a Hospital in Northern Taiwan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infection Using Real-time RT-PCR in a Hospital in Northern Taiwan
Creator	Kao, Chuan-Liang Huang, Li-Min Huang, Fu-Yuan Lee, Ping-Ing Chang, Luan-Yin Lu, Chun-Yi Shao, Pei-Lan Chiang, Yu-Ping Chan, Pei-Chun Chang, Po-Young Chen, Jung-Min Lee, Chin-Yun Wang, Chung-Yi Wu, Ping-Sheng Yang, Tsao-Ton
Source	Elsevier; Medline; PMC
abstract	Background/purpose Human metapneumovirus (hMPV) is a newly discovered respiratory pathogen. This prospective hospital-based study investigated the clinical role and features of hMPV in Taiwan. Methods Respiratory specimens collected from hospitalized children with acute respiratory tract infection between September 1, 2003 and April 10, 2005 were screened for metapneumovirus using real-time reverse transcription-polymerase chain reaction (RT-PCR). Results During the study period, 930 specimens were obtained from 926 hospitalized children. After exclusion of 200 cases due to lack of clinical evidence of airway infection or diseases with known etiology, 726 were included in the analysis. Among these, 33 children had a positive result for hMPV infection. The majority of these patients were admitted during spring and early summer. Twenty-one (63.6%) were younger than 2 years of age. hMPV accounted for 13.3% of respiratory infections occurring between the ages of 18 and 24 months and was as common a respiratory pathogen as respiratory syncytial virus (RSV) in that age group. The 11 patients (33.3%) with underlying diseases had a similar disease course to those without underlying diseases. A co-pathogen was found in 11 patients (33.3%). Infected children between 2 and 5 years of age had significantly higher titers of hMPV in their respiratory specimens (103.88 copies/mL) than children younger than 2 years (102.26 copies/mL) (p = 0.013) and children older than 5 years (102.25 copies/mL) (p = 0.005). hMPV positive cases were significantly older than those with RSV infection (p = 0.002) and had a shorter duration of hospitalization (p = 0.001), fewer days of oxygen use (p = 0.001) and higher levels of C-reactive protein (p = 0.004). Conclusion Metapneumovirus circulates in children in northern Taiwan during spring and early summer. hMPV was the most common respiratory pathogen in children aged between 18 and 24 months hospitalized with acute respiratory tract infection. Real-time RT-PCR is a sensitive method for investigating the epidemiology and diseases associated with hMPV. [J Formos Med Assoc 2007;106(1):16-24]
has issue date	2007-12-31(xsd:dateTime)
bibo:doi	10.1016/s0929-6646(09)60211-4
bibo:pmid	17282966
has license	els-covid
sha1sum (hex)	c40a9d8b962ea6e3ca04db55e1ca65ac408e796f
schema:url	https://doi.org/10.1016/s0929-6646%2809%2960211-4
resource representing a document's title	Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infection Using Real-time RT-PCR in a Hospital in Northern Taiwan
has PubMed Central identifier	PMC7135508
has PubMed identifier	17282966
schema:publication	Journal of the Formosan Medical Association
resource representing a document's body	covid:c40a9d8b962ea6e3ca04db55e1ca65ac408e796f#body_text
is schema:about of	named entity 'HOSPITALIZED CHILDREN' named entity 'NORTHERN' named entity 'shorter' named entity 'age' named entity 'infection' named entity 'respiratory' named entity 'patients' named entity 'respiratory infections' named entity 'respiratory' named entity 'early summer' named entity 'study' named entity 'ACUTE RESPIRATORY TRACT INFECTION' named entity 'CLINICAL' named entity 'PATIENTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'CLINICAL ROLE' named entity 'MED' named entity 'MAJORITY' named entity 'SENSITIVE' named entity 'AGED' named entity 'METHODS' named entity 'DISEASE COURSE' named entity '24 MONTHS' named entity 'RSV INFECTION' named entity 'INVESTIGATED' named entity 'POSITIVE' named entity 'HOSPITAL' named entity 'PCR' named entity 'COMMON' named entity 'PROSPECTIVE' named entity 'EARLY' named entity 'TWENTY-ONE' named entity 'ASSOC' named entity 'METHOD' named entity '0.001' named entity 'NEWLY DISCOVERED' named entity 'PERIOD' named entity 'UNDERLYING' named entity 'OBTAINED' named entity 'DURATION OF HOSPITALIZATION' covid:arg/c40a9d8b962ea6e3ca04db55e1ca65ac408e796f named entity 'AGE GROUP' named entity 'HOSPITALIZED CHILDREN' named entity 'SPECIMENS' named entity 'SUMMER' named entity 'THESE' named entity 'ADMITTED' named entity 'EVIDENCE OF' named entity 'LEVELS' named entity 'USING' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'REAL-TIME RT-PCR' named entity 'HOSPITAL' named entity 'TAIWAN' named entity 'FOUND' named entity 'BACKGROUND' named entity '10%' named entity 'INFECTED' named entity 'SIMILAR' named entity 'RESULTS' named entity 'DETECTION' named entity 'USING' named entity 'ASSOCIATED WITH' named entity 'AGE' named entity 'AGES' named entity '930' named entity 'HUMAN METAPNEUMOVIRUS'

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