About: The Combination of Tocilizumab and Methylprednisolone Along With Initial Lung Recruitment Strategy in Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation: A Series of 21 Consecutive Cases

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About: The Combination of Tocilizumab and Methylprednisolone Along With Initial Lung Recruitment Strategy in Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation: A Series of 21 Consecutive Cases Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Combination of Tocilizumab and Methylprednisolone Along With Initial Lung Recruitment Strategy in Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation: A Series of 21 Consecutive Cases
Creator	Doebele, Rebecca Faust, Andrew Feldman, Mark Gary, ; Hazbun, Munir Kenney, ; Liddell, Allison Ortegon, Anthony Sheperd, Lyndsay Weinmeister, D Weinstein, L
Source	Medline; PMC
abstract	OBJECTIVE: To describe the outcomes with use of a combination of tocilizumab and methylprednisolone administered around the time of endotracheal intubation in patients with confirmed coronavirus disease 2019-associated hypoxemic respiratory failure requiring mechanical ventilation. DATA SOURCES: Retrospective chart review. STUDY SELECTION/DATA EXTRACTION: Twenty-one consecutive patients with confirmed coronavirus disease 2019-associated hypoxemic respiratory failure requiring mechanical ventilation. Initial ventilator parameters were positive end-expiratory pressure 14 cm H(2)o and target plateau pressure 29 cm H(2)o to maximize lung recruitment. Methylprednisolone (125 mg every 6hr for 24 hr with tapering to 60 mg every 12 hr) was administered shortly after patients were intubated (median 11 hr after intubation). DATA SYNTHESIS: No patient in the cohort died while hospitalized (mortality, 0%; 95% CI, 0%–18%) and 18 patients have been discharged from the acute care setting. Twenty of 21 patients (95%) have been liberated from mechanical ventilation after a median duration of 8 days (range, 4–30 d). Following 48 hours of methylprednisolone, the A-a o(2) gradient decreased from 455 ± 103 to 228 ± 109 mm Hg (difference 227 ± 108 mm Hg; p < 0.01). CONCLUSIONS: Our positive experience with tocilizumab in combination with methylprednisolone started early after endotracheal intubation may be one avenue for reducing the morbidity and mortality seen with severe coronavirus disease 2019 and merits further exploration in clinical studies.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1097/cce.0000000000000145
bibo:pmid	32696008
has license	cc-by-nc-nd
sha1sum (hex)	c423459ca6751a92cd1f7ee225ea15af34b38982
schema:url	https://doi.org/10.1097/cce.0000000000000145
resource representing a document's title	The Combination of Tocilizumab and Methylprednisolone Along With Initial Lung Recruitment Strategy in Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation: A Series of 21 Consecutive Cases
has PubMed Central identifier	PMC7314352
has PubMed identifier	32696008
schema:publication	Crit Care Explor
resource representing a document's body	covid:c423459ca6751a92cd1f7ee225ea15af34b38982#body_text
is schema:about of	named entity 'hypoxemic' named entity 'methylprednisolone' named entity 'Sources' named entity 'With' named entity 'Ventilation' named entity 'Patients' named entity 'Cases' named entity '2 O' named entity 'PARAMETERS' named entity 'PATIENTS' named entity 'ENDOTRACHEAL INTUBATION' named entity 'METHYLPREDNISOLONE' named entity 'H 2' named entity 'COMBINATION' named entity 'patients' named entity 'plateau' named entity 'Coronavirus' named entity 'endotracheal intubation' named entity 'Data Extraction' named entity 'mechanical ventilation' named entity 'coronavirus disease 2019' named entity 'respiratory failure' named entity 'hypoxemic' named entity 'PEEP' named entity 'intubation' named entity 'polymerase chain reaction' named entity 'critically ill' named entity 'COVID-19' named entity 'intensive care' named entity 'extubation' named entity 'COVID' named entity 'ARDS' named entity 'COVID' named entity '2, 3' named entity 'PEEP' named entity 'COVID' named entity 'COVID-19' named entity 'clinical studies' named entity 'methylprednisolone' named entity 'Ferritin' named entity 'Tocilizumab' named entity 'fluid overload' named entity 'IMV' named entity 'plateau pressure' named entity 'antiviral' named entity 'methylprednisolone' named entity 'case series' named entity 'methylprednisolone' named entity 'skilled nursing unit' named entity 'glucocorticoid' named entity 'BMI' named entity 'mechanical ventilation' named entity 'intravascular' named entity 'antiviral' named entity 'methylprednisolone' named entity 'tocilizumab' named entity '10.5' named entity 'respiratory failure' named entity 'nasal cannula' named entity 'Retrospective chart review' named entity 'infection' named entity 'IMV' named entity 'ventilator' named entity 'host response' named entity 'Tocilizumab' named entity 'lung' named entity 'salvage therapy' named entity 'glucocorticoids' named entity 'respiratory distress' named entity 'SARS-CoV' named entity 'respiratory failure'

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