About: Monocaprin eye drop formulation to combat antibiotic resistant gonococcal blindness

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About: Monocaprin eye drop formulation to combat antibiotic resistant gonococcal blindness Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Monocaprin eye drop formulation to combat antibiotic resistant gonococcal blindness
Creator	Snyder, Lori Abdelkader, Hamdy Al-Kinani, Ali Alany, Raid Churchward, Colin Swinden, Julian Varnakulasingam, Thinuba
Source	Medline; PMC
abstract	Neisseria gonorrhoeae bacteria are acknowledged as an urgent threat to human health because this species has developed resistances to all of the antibiotics used clinically to treat its infections. N. gonorrhoeae causes the sexually transmitted disease gonorrhoea, but also causes blindness when the bacteria infect the eyes. Infants are particularly susceptible, acquiring the infection from their mothers at birth. We have shown that the monoglyceride monocaprin rapidly kills N. gonorrhoeae and other bacterial species and is non-irritating in ocular assays. Here we show that the physical and chemical properties of monocaprin make it ideal for use in a thickened eye drop formulation to combat eye infections. Monocaprin-containing formulations were assessed using analytical techniques and for antimicrobial activity in vitro and in ex vivo infections. Monocaprin-containing formulations retained activity after three years and are non-irritating, unlike preparations of povidone iodine in our assays. A recommended formulation for further development and investigation is 0.25% monocaprin in 1% HPMC with 1% polysorbate 20.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1038/s41598-020-68722-8
bibo:pmid	32694582
has license	cc-by
sha1sum (hex)	c42c06db40a3409006b2ae54319eedabb720d71a
schema:url	https://doi.org/10.1038/s41598-020-68722-8
resource representing a document's title	Monocaprin eye drop formulation to combat antibiotic resistant gonococcal blindness
has PubMed Central identifier	PMC7374094
has PubMed identifier	32694582
schema:publication	Sci Rep
resource representing a document's body	covid:c42c06db40a3409006b2ae54319eedabb720d71a#body_text
is schema:about of	named entity 'vivo' named entity 'human health' named entity 'bacteria' named entity 'N. gonorrhoeae' named entity 'eye drop' named entity 'CAUSES' named entity 'HUMAN HEALTH' named entity 'THEIR' named entity 'AT BIRTH' named entity 'bacteria' named entity 'rapidly' named entity 'assays' named entity 'infection' named entity 'combat' named entity 'bacteria' named entity 'Neisseria gonorrhoeae' named entity 'infection' named entity 'N. gonorrhoeae' named entity 'blindness' named entity 'N. gonorrhoeae' named entity 'eye drop' named entity 'sexually transmitted disease' named entity 'acetonitrile' named entity 'diffusion rate' named entity 'prophylaxis' named entity 'gonococcal' named entity 'erythromycin' named entity 'saline' named entity 'antibiotics' named entity 'HPMC' named entity 'N. gonorrhoeae' named entity 'ophthalmia neonatorum' named entity 'toxicity' named entity 'white petroleum' named entity 'gonococcal infection' named entity 'high performance liquid chromatography' named entity 'Saponin' named entity 'silver nitrate' named entity 'white petroleum' named entity 'gonococcal' named entity 'diode array detector' named entity 'propane-1,2-diol' named entity 'ointment' named entity 'Perkin Elmer' named entity 'gonococcal' named entity 'saponin' named entity 'national guidelines' named entity 'polysorbates' named entity 'chloramphenicol' named entity 'bacteria' named entity 'ophthalmia' named entity 'antibiotics' named entity 'ceftriaxone' named entity 'normal saline' named entity 'prophylaxis' named entity 'positive control' named entity 'prophylaxis' named entity 'distilled water' named entity 'World Health Organisation' named entity 'antimicrobial activity' named entity 'gonococci' named entity 'chloramphenicol' named entity 'ppm' named entity 'HPMC' named entity 'COVID-19' named entity 'negative control' named entity 'HPMC' named entity 'USP' named entity 'eye drop' named entity 'bacteriostatic' named entity 'isocratic' named entity 'clinical studies' named entity 'solubility' named entity 'N. gonorrhoeae' named entity 'polysorbate 20'

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