About: Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis
Creator	Huang, Ian Pranata, Raymond
Source	Medline; PMC
abstract	OBJECTIVE: Clinical and laboratory biomarkers to predict the severity of coronavirus disease 2019 (COVID-19) are essential in this pandemic situation of which resource allocation must be urgently prepared especially in the context of respiratory support readiness. Lymphocyte count has been a marker of interest since the first COVID-19 publication. We conducted a systematic review and meta-analysis in order to investigate the association of lymphocyte count on admission and the severity of COVID-19. We would also like to analyze whether patient characteristics such as age and comorbidities affect the relationship between lymphocyte count and COVID-19. METHODS: Comprehensive and systematic literature search was performed from PubMed, SCOPUS, EuropePMC, ProQuest, Cochrane Central Databases, and Google Scholar. Research articles in adult patients diagnosed with COVID-19 with information on lymphocyte count and several outcomes of interest, including mortality, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) care, and severe COVID-19, were included in the analysis. Inverse variance method was used to obtain mean differences and its standard deviations. Maentel-Haenszel formula was used to calculate dichotomous variables to obtain odds ratios (ORs) along with its 95% confidence intervals. Random-effect models were used for meta-analysis regardless of heterogeneity. Restricted-maximum likelihood random-effects meta-regression was performed for age, gender, cardiac comorbidity, hypertension, diabetes mellitus, COPD, and smoking. RESULTS: There were a total of 3099 patients from 24 studies. Meta-analysis showed that patients with poor outcome have a lower lymphocyte count (mean difference − 361.06 μL [− 439.18, − 282.95], p < 0.001; I(2) 84%) compared to those with good outcome. Subgroup analysis showed lower lymphocyte count in patients who died (mean difference − 395.35 μL [− 165.64, − 625.07], p < 0.001; I(2) 87%), experienced ARDS (mean difference − 377.56 μL [− 271.89, − 483.22], p < 0.001; I(2) 0%), received ICU care (mean difference − 376.53 μL [− 682.84, − 70.22], p = 0.02; I(2) 89%), and have severe COVID-19 (mean difference − 353.34 μL [− 250.94, − 455.73], p < 0.001; I(2) 85%). Lymphopenia was associated with severe COVID-19 (OR 3.70 [2.44, 5.63], p < 0.001; I(2) 40%). Meta-regression showed that the association between lymphocyte count and composite poor outcome was affected by age (p = 0.034). CONCLUSION: This meta-analysis showed that lymphopenia on admission was associated with poor outcome in patients with COVID-19.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.1186/s40560-020-00453-4
bibo:pmid	32483488
has license	cc-by
sha1sum (hex)	c4495a674f2cb4c817fdeb3cdaf562cbc8657f08
schema:url	https://doi.org/10.1186/s40560-020-00453-4
resource representing a document's title	Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis
has PubMed Central identifier	PMC7245646
has PubMed identifier	32483488
schema:publication	J Intensive Care
resource representing a document's body	covid:c4495a674f2cb4c817fdeb3cdaf562cbc8657f08#body_text
is schema:about of	named entity 'received' named entity 'age' named entity 'literature' named entity 'COVID-19' named entity 'count' named entity 'resource allocation' named entity 'likelihood' named entity 'COVID-19' named entity 'support' named entity 'Lymphopenia' named entity 'patients' named entity 'acute respiratory distress syndrome (ARDS)' named entity 'COMPOSITE' named entity 'SEVERITY' named entity 'STANDARD' named entity 'LIKELIHOOD' named entity 'MEAN' named entity 'SITUATION' named entity 'COMORBIDITIES' named entity 'VARIANCE' named entity 'ODDS RATIOS' named entity 'ANALYSIS' named entity 'PERFORMED' named entity 'SCHOLAR' named entity 'total' named entity 'patients' named entity 'systematic' named entity 'lymphocyte count' named entity 'predict' named entity 'laboratory' named entity 'smoking' named entity 'heterogeneity' named entity 'order' named entity 'dichotomous' named entity 'standard deviations' named entity 'adult' named entity 'COVID-19' named entity 'SCOPUS' named entity 'COVID-19' named entity 'lymphocyte count' named entity 'investigate' named entity 'calculate' named entity 'ProQuest' named entity 'There' named entity 'Subgroup analysis' named entity 'lymphocyte count' named entity 'COVID-19' named entity 'meta-analysis' named entity 'heterogeneity' named entity 'literature search' named entity 'dichotomous' named entity 'acute respiratory distress syndrome' named entity 'resource allocation' named entity 'systematic review' named entity 'comorbidity' named entity 'COVID' named entity 'lymphocyte count' named entity 'studies' named entity 'hypertensive' named entity 'sensitivity analysis' named entity 'Regression-based' named entity 'MERS-CoV' named entity 'research articles' named entity 'lymphocyte count' named entity 'COVID' named entity 'WHO' named entity 'enzyme' named entity 'oxygen' named entity 'older patients' named entity 'meta-analysis' named entity 'hypertension' named entity 'Angiotensin-converting enzyme' named entity 'subgroup analysis' named entity 'MOF' named entity 'Data extraction' named entity 'older patients' named entity 'angiotensin II' named entity 'lymphopenia' named entity 'Regression-based' named entity 'severe acute respiratory syndrome'

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