About: The predicative clinical features associated with chronic cough that has a single underlying cause

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The predicative clinical features associated with chronic cough that has a single underlying cause
Creator	Zhong, Nanshan Peng, Wen Luo, Wei Lai, Kefang Li, Hu Zhou, Jianmeng Tang, Zhou Zhang, Liting Chen, Ruchong Long, Li Zhan, Wenzhi Yi, Fang Chen, Qiaoli Li, Zhan Tang, Jiaman Zhong, Meijiang
source	Elsevier; Medline; PMC
abstract	Abstract Background Few studies have investigated the usefulness of the clinical characteristics of cough in the diagnosis of chronic cough. Objective To evaluate the diagnostic value of clinical characteristics and concomitant symptoms of chronic cough in predicting its cause． Methods We recruited adult patients with chronic cough as a primary presenting symptom and identified those with a single underlying cause. Clinical features of cough were recorded with a custom-designed questionnaire and its relationship with cause of cough were analyzed. Results A total of 1162 patients with a single underlying cause were enrolled. Nocturnal cough alone was a predictor of cough variant asthma [odds ratio (OR) 2.037, 95% CI 1.003-4.139] with high specificity (97.6%) and low sensitivity (8.1%). Heartburn (OR 2.671, 95% CI 1.544-4.620), belching (OR 2.536, 95% CI 1.620-3.971), acid regurgitation (OR 2.043, 95% CI 1.299-3.212) indicated gastroesophageal reflux-related cough with high specificity (85.5%-94.9%) and low sensitivity (22.8%-40.7%). Cough after meals had a high specificity (91.2%) and a low sensitivity (24.8%) for gastroesophageal reflux-related cough. Postnasal dripping (OR 2.317, 95% CI 1.425-3.767) and history of sinusitis (OR 4.137, 95% CI 2.483-6.892) were indicators for upper airway cough syndrome with high specificity (80.8% and 90.2% respectively). Rhinitis/sinusitis-related symptoms showed moderate sensitivity (72.9%), however, they showed mild specificity (46.1%) for upper airway cough syndrome. Conclusion Cough timing, several concomitant symptoms associated with gastroesophageal reflux or rhinitis/sinusitis, and medical history are useful to indicate common causes of chronic cough.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1016/j.jaip.2020.06.066
bibo:pmid	32693212
has license	els-covid
sha1sum (hex)	c44eef8f9a861369f95bc3444d55fa6abcdb5233
schema:url	https://doi.org/10.1016/j.jaip.2020.06.066
resource representing a document's title	The predicative clinical features associated with chronic cough that has a single underlying cause
has PubMed Central identifier	PMC7368645
has PubMed identifier	32693212
schema:publication	J Allergy Clin Immunol Pract
resource representing a document's body	covid:c44eef8f9a861369f95bc3444d55fa6abcdb5233#body_text
is schema:about of	named entity 'Journal' named entity 'predicative' named entity 'predicative' named entity 'CLINICAL FEATURES' named entity 'chronic cough' named entity 'clinical features' named entity 'cough' named entity 'primary care' named entity 'physiological' named entity 'nocturnal cough' named entity 'gastroesophageal reflux' named entity 'cough' named entity 'cough' named entity 'sinusitis' named entity 'morbidity' named entity 'cough' named entity 'significant difference' named entity 'regurgitation' named entity 'cough' named entity 'belching' named entity 'sinusitis' named entity 'Cough' named entity 'cough' named entity 'upper airway cough syndrome' named entity 'Rhinitis' named entity 'airway' named entity 'cough' named entity 'clinical characteristics' named entity '1.544' named entity 'gastroesophageal reflux' named entity 'cough' named entity 'Heartburn' named entity 'clinical features' named entity 'clinical features' named entity 'chronic cough' named entity 'UNDERLYING' named entity 'ASSOCIATED WITH' named entity 'SINGLE' named entity 'single' named entity 'features' named entity 'chronic cough' named entity 'chronic' named entity 'features' named entity 'CHRONIC COUGH' named entity 'single' named entity 'JOURNAL ' named entity 'PRE' named entity 'ASSOCIATED WITH' named entity 'chronic cough' named entity 'CAUSE' named entity 'CHRONIC' named entity 'CLINICAL FEATURES' named entity 'CHRONIC COUGH' named entity 'SINGLE' named entity 'UNDERLYING' named entity 'CAUSE' named entity 'PROOF'
is part of of	covid:c44eef8f9a861369f95bc3444d55fa6abcdb5233#body_text Abstract Background Few studies have investigated the usefulness of the clinical characteristics of cough in the diagnosis of chronic cough. Objective To evaluate the diagnostic value of clinical characteristics and concomitant symptoms of chronic cough in predicting its cause． Methods We recruited adult patients with chronic cough as a primary presenting symptom and identified those with a single underlying cause. Clinical features of cough were recorded with a custom-designed questionnaire and its relationship with cause of cough were analyzed. Results A total of 1162 patients with a single underlying cause were enrolled. Nocturnal cough alone was a predictor of cough variant asthma [odds ratio (OR) 2.037, 95% CI 1.003-4.139] with high specificity (97.6%) and low sensitivity (8.1%). Heartburn (OR 2.671, 95% CI 1.544-4.620), belching (OR 2.536, 95% CI 1.620-3.971), acid regurgitation (OR 2.043, 95% CI 1.299-3.212) indicated gastroesophageal reflux-related cough with high specificity (85.5%-94.9%) and low sensitivity (22.8%-40.7%). Cough after meals had a high specificity (91.2%) and a low sensitivity (24.8%) for gastroesophageal reflux-related cough. Postnasal dripping (OR 2.317, 95% CI 1.425-3.767) and history of sinusitis (OR 4.137, 95% CI 2.483-6.892) were indicators for upper airway cough syndrome with high specificity (80.8% and 90.2% respectively). Rhinitis/sinusitis-related symptoms showed moderate sensitivity (72.9%), however, they showed mild specificity (46.1%) for upper airway cough syndrome. Conclusion Cough timing, several concomitant symptoms associated with gastroesophageal reflux or rhinitis/sinusitis, and medical history are useful to indicate common causes of chronic cough. The predicative clinical features associated with chronic cough that has a single underlying cause

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