About: Assessment of the safety and efficacy of an attenuated live vaccine based on highly virulent genotype 2b porcine epidemic diarrhea virus in nursing piglets

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About: Assessment of the safety and efficacy of an attenuated live vaccine based on highly virulent genotype 2b porcine epidemic diarrhea virus in nursing piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessment of the safety and efficacy of an attenuated live vaccine based on highly virulent genotype 2b porcine epidemic diarrhea virus in nursing piglets
Creator	Lee, Changhee Lee, Seung-Chul Jang, Guehwan Choi, Hwan-Won Lee, Dong-Uk Noh, Yun-Hee Won, Hokeun Yoon, In-Joong Lee, Yoo Yoo, Han
Source	Elsevier; Medline; PMC
abstract	We have previously reported the generation of the attenuated KNU-141112-S DEL5/ORF3 virus by continuous propagation of highly virulent G2b porcine epidemic diarrhea virus (PEDV) in Vero cells. The present study aimed to assess the safety of S DEL5/ORF3 and to evaluate its effectiveness as a live vaccine for prime-booster vaccinations. Reversion to virulence experiments revealed that the S DEL5/ORF3 strain retains its attenuated phenotype and genetic stability after five successive passages in susceptible piglets. Pregnant sows were primed orally with an S DEL5/ORF3 live vaccine and boosted intramuscularly twice with a commercial killed vaccine at 2-week intervals prior to parturition. This sow vaccination regimen completely protected nursing piglets against virulent G2b challenge, as evidenced by the increase in survival rate from 0% to 100% and the significant reduction in diarrhea intensity, including the amount and duration of PEDV fecal shedding. In addition, despite a 2–3 day period of weight loss in piglets from vaccinated sows after challenge, their daily weight gain was recovered at 7 days post-challenge and became similar to that of unchallenged pigs from unvaccinated sows over the course of the experiment. Furthermore, strong antibody responses to PEDV were verified in the sera and colostrum of immunized sows with the prime-boost treatment and their offspring. Altogether, our data demonstrated that the attenuated S DEL5/ORF3 strain guarantees the safety to host animals with no reversion to virulence and is suitable as an effective primary live vaccine providing durable maternal lactogenic immunity for passive piglet protection.
has issue date	2019-03-11(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.03.009
bibo:pmid	30955799
has license	no-cc
sha1sum (hex)	c4605351a6f163494f4d470cbc57eb2194af2ca1
schema:url	https://doi.org/10.1016/j.vetmic.2019.03.009
resource representing a document's title	Assessment of the safety and efficacy of an attenuated live vaccine based on highly virulent genotype 2b porcine epidemic diarrhea virus in nursing piglets
has PubMed Central identifier	PMC7117296
has PubMed identifier	30955799
schema:publication	Vet Microbiol
resource representing a document's body	covid:c4605351a6f163494f4d470cbc57eb2194af2ca1#body_text
is schema:about of	named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'safety' named entity 'completely' named entity 'primary' named entity 'guarantees' named entity 'day' named entity 'immunized' named entity 'vaccination' named entity 'PREVIOUSLY' named entity 'STRONG' named entity 'VIRULENT' named entity 'PIGLET' named entity 'HIGHLY' named entity 'PASSIVE' named entity 'COLOSTRUM' named entity 'VACCINATED' named entity 'EXPERIMENTS' named entity 'SOW' named entity 'IMMUNITY' named entity 'INCREASE' named entity 'SERA' named entity 'PROTECTION' named entity 'RETAINS' named entity 'MATERNAL' named entity 'RECOVERED' named entity 'RESPONSES' named entity 'VERIFIED' named entity 'ANIMALS' named entity 'HAVE' named entity 'WEIGHT GAIN' named entity 'PRIMED' named entity 'ORALLY' named entity 'REDUCTION' named entity 'SOWS' named entity 'HOST' named entity 'STUDY' named entity 'OUR' named entity 'EFFECTIVE' named entity 'NURSING' named entity 'SURVIVAL RATE' named entity 'ATTENUATED LIVE VACCINE' named entity 'GENOTYPE' named entity 'ASSESSMENT' named entity 'PRESENT' named entity 'INCLUDING' named entity 'PARTURITION' named entity 'BOOST' named entity 'VIRULENCE' named entity 'PHENOTYPE' named entity 'FECAL' named entity 'PROPAGATION' named entity 'REGIMEN' named entity 'DAILY' named entity 'SUCCESSIVE' named entity 'OFFSPRING' named entity 'COMMERCIAL' named entity 'VIRUS' named entity 'PERIOD' named entity 'PRIOR TO' named entity 'UNVACCINATED' named entity 'KNU' named entity 'INTENSITY' named entity 'ATTENUATED' named entity 'INTERVALS' named entity 'WEEK' named entity 'CONTINUOUS' named entity 'DAY' named entity 'EFFECTIVENESS' named entity 'PIGS' named entity 'PRIMARY' named entity 'SIMILAR' named entity 'VIRULENT'

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