About: RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336”

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336” Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336”
Creator	Burgess, S Cooksey, A Kumar, R Lawrence, M Watt, J
Source	PMC
abstract	Genome structural annotation, i.e., identification and demarcation of the boundaries for all the functional elements in a genome (e.g., genes, non-coding RNAs, proteins and regulatory elements), is a prerequisite for systems level analysis. Current genome annotation programs do not identify all of the functional elements of the genome, especially small non-coding RNAs (sRNAs). Whole genome transcriptome analysis is a complementary method to identify “novel” genes, small RNAs, regulatory regions, and operon structures, thus improving the structural annotation in bacteria. In particular, the identification of non-coding RNAs has revealed their widespread occurrence and functional importance in gene regulation, stress and virulence. However, very little is known about non-coding transcripts in Histophilus somni, one of the causative agents of Bovine Respiratory Disease (BRD) as well as bovine infertility, abortion, septicemia, arthritis, myocarditis, and thrombotic meningoencephalitis. In this study, we report a single nucleotide resolution transcriptome map of H. somni strain 2336 using RNA-Seq method. The RNA-Seq based transcriptome map identified 94 sRNAs in the H. somni genome of which 82 sRNAs were never predicted or reported in earlier studies. We also identified 38 novel potential protein coding open reading frames that were absent in the current genome annotation. The transcriptome map allowed the identification of 278 operon (total 730 genes) structures in the genome. When compared with the genome sequence of a non-virulent strain 129Pt, a disproportionate number of sRNAs (∼30%) were located in genomic region unique to strain 2336 (∼18% of the total genome). This observation suggests that a number of the newly identified sRNAs in strain 2336 may be involved in strain-specific adaptations.
has issue date	2012-01-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0029435
bibo:pmid	22276113
has license	cc-by
sha1sum (hex)	c46224620e6c2f039588f57d5133dedd75941da5
schema:url	https://doi.org/10.1371/journal.pone.0029435
resource representing a document's title	RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336”
has PubMed Central identifier	PMC3262788
has PubMed identifier	22276113
schema:publication	PLoS One
resource representing a document's body	covid:c46224620e6c2f039588f57d5133dedd75941da5#body_text
is schema:about of	named entity 'MAP' named entity 'RNA-SEQ ' named entity 'ABORTION' named entity 'GENOME' named entity 'ELEMENTS' named entity 'NOVEL' named entity 'CAUSATIVE AGENTS' named entity 'REPORTED' named entity 'ABOUT' named entity 'GENOME ANNOTATION' named entity 'STRAIN' named entity 'ADAPTATIONS' named entity 'IDENTIFICATION' named entity 'KNOWN' named entity 'THROMBOTIC' named entity 'BOVINE RESPIRATORY DISEASE' named entity 'SINGLE' named entity 'TOTAL' named entity 'IMPROVING' named entity 'POTENTIAL' named entity 'BOUNDARIES' named entity 'REGULATORY' named entity 'EARLIER' named entity 'IDENTIFY' named entity 'TO IDENTIFY' named entity 'GENOME SEQUENCE' named entity 'SEPTICEMIA' named entity 'MAP' named entity 'TRANSCRIPTIONAL' named entity 'PATHOGEN' named entity 'RNA-SEQ ' named entity 'USING' named entity 'METHOD' named entity 'UNIQUE' named entity 'IDENTIFIED' named entity 'STRESS' named entity 'REVEALED' named entity 'CURRENT' named entity 'PREREQUISITE' named entity 'REGIONS' named entity 'DO NOT' named entity 'REGION' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'OCCURRENCE' named entity 'TRANSCRIPTS' named entity 'OPEN READING FRAMES' named entity 'RNAS' named entity 'BASED' named entity 'INVOLVED' named entity 'NUMBER OF' named entity '2C18' named entity 'PREDICTED' named entity 'IS A' named entity 'LOCATED IN' named entity 'HISTOPHILUS SOMNI' named entity 'SPECIFIC' named entity 'FUNCTIONAL' named entity 'SYSTEMS' named entity 'ALLOWED' named entity 'NEVER' named entity 'DISPROPORTIONATE' named entity 'MENINGOENCEPHALITIS' named entity 'BOVINE' named entity 'RNA-SEQ METHOD' named entity 'NUCLEOTIDE' named entity 'RESOLUTION' named entity 'ANALYSIS' named entity 'PROGRAMS' named entity 'PROTEINS' named entity 'ANNOTATION' named entity 'GENE REGULATION' named entity 'VIRULENT STRAIN' named entity 'OPERON' named entity 'CODING' named entity 'STRUCTURAL' named entity 'PROTEIN ' named entity 'PARTICULAR'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software