About: Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit
Creator	Li, Lanjuan Zheng, Shufa Yu, Liang Ding, Wei Shi, Ding Zhou, Ning Liu, Jimin Zhang, Yimin
Source	Medline; PMC
abstract	Avian influenza A(H7N9) virus (A(H7N9)) emerged in February 2013. Liver impairment of unknown cause is present in 29% of patients with A(H7N9) infection, some of whom experience severe liver injury. Hypoxic hepatitis (HH) is a type of acute severe liver injury characterized by an abrupt, massive increase in serum aminotransferases resulting from anoxic centrilobular necrosis of liver cells. In the intensive care unit (ICU), the prevalence of HH is ∼1%–2%. Here, we report a 1.8% (2/112) incidence of HH in the largest single-centre cohort of ICU patients with A(H7N9) infection. Both HH patients presented with multiple organ failure (MOF) involving respiratory, cardiac, circulatory and renal failure and had a history of chronic heart disease. On admission, severe liver impairment was found. Peak alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values were 937 and 1281 U/L, and 3117 and 3029 U/L, respectively, in the two patients. Unfortunately, both patients died due to deterioration of MOF. A post-mortem biopsy in case 1 confirmed the presence of centrilobular necrosis of the liver, and real-time reverse transcription polymerase chain reaction of A(H7N9)-specific genes was negative, which excluded A(H7N9)-related hepatitis. The incidence of HH in A(H7N9) patients is similar to that in ICU patients with other aetiologies. It seems that patients with A(H7N9) infection and a history of chronic heart disease with a low left ventricular ejection fraction on admission are susceptible to HH, which presents as a marked elevation in ALT at the time of admission.
has issue date	2016-01-06(xsd:dateTime)
bibo:doi	10.1038/emi.2016.1
bibo:pmid	26733380
has license	cc-by
sha1sum (hex)	c481fdcf995099e14997dabd9fe3b47ce8784020
schema:url	https://doi.org/10.1038/emi.2016.1
resource representing a document's title	Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit
has PubMed Central identifier	PMC4735056
has PubMed identifier	26733380
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:c481fdcf995099e14997dabd9fe3b47ce8784020#body_text
is schema:about of	named entity 'liver' named entity 'INTENSIVE CARE UNIT' named entity 'INFECTED' named entity 'LIVER' named entity 'LARGEST' named entity 'SEVERE' named entity 'SINGLE' named entity 'AVIAN INFLUENZA A' named entity 'PREVALENCE' named entity 'IMPAIRMENT' named entity 'HEPATITIS' named entity 'CENTRE' named entity 'COHORT' named entity 'CHARACTERISTICS' named entity 'HYPOXIC' named entity 'PATIENTS' named entity 'VIRUS' named entity 'liver impairment' named entity 'Prevalence' named entity 'hypoxic' named entity 'H7N9' named entity 'norepinephrine' named entity 'respiratory failure' named entity 'Post-mortem' named entity 'mortality rate' named entity 'mmol/L' named entity 'liver' named entity 'oxygen supply' named entity 'liver impairment' named entity 'cytomegalovirus' named entity 'coronary heart disease' named entity 'H7N9' named entity 'infection' named entity 'arterial pressure' named entity 'biopsies' named entity 'lung' named entity 'ICU' named entity 'reduced oxygen' named entity 't-test' named entity 'hypoxic' named entity 'kidney' named entity 'hepatocytes' named entity 'Liver ultrasound' named entity 'poultry' named entity 'liver injury' named entity 'post-mortem' named entity 'transfusion' named entity 'LDH' named entity 'liver impairment' named entity 'liver biopsy' named entity 'kidney' named entity 'liver injury' named entity 'mortality rate' named entity 'liver impairment' named entity 'liver injury' named entity 'inflammation' named entity 'real-time RT-PCR' named entity 'formalin' named entity 'renal tubule' named entity 'early diagnosis' named entity 'haematoxylin' named entity 'hepatitis' named entity 'ICU' named entity 'viral hepatitis' named entity 'myocarditis' named entity 'hypertension' named entity 'aminotransferase' named entity 'H7N9' named entity 'H7N9' named entity 'risk factors' named entity 'ICU' named entity 'inflammation' named entity 'Antiviral therapy' named entity 'mmol/L'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software