About: Post-translational Control of Intracellular Pathogen Sensing Pathways

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Post-translational Control of Intracellular Pathogen Sensing Pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Post-translational Control of Intracellular Pathogen Sensing Pathways
Source	Elsevier; Medline; PMC
abstract	Mammalian cells recognize virus-derived nucleic acids using a defined set of intracellular sensors including the DNA sensors cyclic GMP–AMP (cGAMP) synthase (cGAS) and interferon gamma (IFNγ)-inducible protein 16 (IFI16) as well as viral RNA receptors of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family. Following innate immune recognition, these sensors launch an immune response that is characterized by the transcriptional upregulation of many antiviral molecules, including proinflammatory cytokines, chemokines, and IFN-stimulated genes. Recent studies have demonstrated that the signal transduction initiated by these sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a robust yet ‘tunable’ cytokine response to maintain immune homeostasis. Here we summarize recent advances in our understanding of how PTMs and regulatory enzymes control the signaling activity of RLRs, cGAS, and IFI16 as well as their proximal adaptor proteins.
has issue date	2017-01-01(xsd:dateTime)
bibo:doi	10.1016/j.it.2016.10.008
bibo:pmid	27863906
has license	green-oa
sha1sum (hex)	c4a77af2848f4c08459e2ce5154ea63a187cf177
schema:url	https://doi.org/10.1016/j.it.2016.10.008
resource representing a document's title	Post-translational Control of Intracellular Pathogen Sensing Pathways
has PubMed Central identifier	PMC5580928
has PubMed identifier	27863906
schema:publication	Trends in Immunology
resource representing a document's body	covid:c4a77af2848f4c08459e2ce5154ea63a187cf177#body_text
is schema:about of	named entity 'TERMINAL' named entity 'adaptor protein' named entity 'proteins' named entity 'interleukins' named entity 'kappa' named entity 'TBK1' named entity 'helicases' named entity 'CTD' named entity 'STRUCTURES' named entity 'DOMAIN' named entity 'KINASES' named entity 'PROTEIN ' named entity 'TYPE I' named entity 'SUPERFAMILY' named entity 'MEMBRANES' named entity 'TRANSLOCATION' named entity 'MITOCHONDRIA' named entity 'IKKB' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'SUBTYPES' named entity 'TRIPARTITE' named entity 'INITIATE' named entity 'MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN' named entity 'IRF3' named entity 'INTERLEUKINS' named entity 'DOWNSTREAM' named entity 'SIMILAR' named entity 'RNA BINDING' named entity 'MAVS' named entity 'IKKG' named entity 'PROGRAM' named entity 'IKKE' named entity 'VISA' named entity 'ANTIVIRAL RESPONSE' named entity 'MEDIATES' named entity 'RIG-I' named entity 'KNOWN' named entity 'INDUCE' named entity 'DEMONSTRATED' named entity 'TANK-BINDING KINASE 1' named entity 'IKK' named entity 'BOX' named entity 'TUMOR NECROSIS FACTOR ' named entity 'NUCLEUS' named entity 'DIFFERENT' named entity 'IPS-1' named entity 'A COMMON' named entity 'IRF7' named entity 'ACTIVATE' named entity 'RELATED' named entity 'ANTIVIRAL' named entity 'ACTIVATION' named entity 'MDA5' named entity 'N-TERMINAL ' named entity 'CONTAINING' named entity 'RIG-I' named entity 'CASPASE ACTIVATION' named entity 'INITIATING' named entity 'CENTRAL' named entity 'HELICASE' named entity 'RNA HELICASES' named entity 'CARBOXY' named entity 'ADAPTOR PROTEIN' named entity 'SIGNALING' named entity 'DOMAIN' named entity 'REQUIRED' named entity 'CYTOSOL' named entity 'TRIGGER' named entity 'IFNB' named entity 'GENE EXPRESSION' named entity 'CASE' named entity 'INITIATION' named entity 'CHAPERONE PROTEIN' named entity 'TRANSLOCATE' named entity '14-3-3E' named entity 'RESULTING IN' named entity 'CHEMOKINES' named entity 'ACTIVATED' named entity 'SERINE' named entity 'INTERACT' named entity 'NUCLEAR FACTOR KAPPA B' named entity 'PROTEINS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software