About: Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference
Creator	Hotta, Hak Kadoya, Hiroyasu Nagano-Fujii, Motoko Otaki, Momoko Sada, Kiyonao
Source	Elsevier; Medline; PMC
abstract	Abstract Subacute sclerosing panencephalitis (SSPE) is a rare, but fatal outcome of measles virus (MeV) infection. SSPE develops after prolonged persistence of mutated MeV called SSPE virus. Although a combination therapy using interferon and inosiplex or ribavirin appears to prolong survival time to some extent, there is currently no effective treatment to completely cure SSPE and a new treatment strategy is greatly needed. In this study, we adopted RNA interference (RNAi) strategy and examined whether small interfering RNAs (siRNAs) can be used to inhibit replication of MeV and SSPE virus. We report here that siRNAs targeted against L mRNA of MeV, either synthetic siRNAs or those generated by pcPUR+U6i-based expression plasmids, effectively and specifically inhibited replication of both MeV and SSPE virus without exhibiting any cytotoxic effect. The L protein of MeV is a major component of RNA-dependent RNA polymerase that is essential for viral RNA replication, and yet it is least abundant among all the MeV proteins expressed. Therefore, mRNA encoding the L protein would be a good target for RNAi strategy. The present results imply the possibility that our siRNAs against MeV L mRNA are among the potential candidates to be used to treat patients with SSPE.
has issue date	2006-07-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2006.01.009
bibo:pmid	16530274
has license	els-covid
sha1sum (hex)	c4b8d416737b7b204d582699cab25f9b5eccc90b
schema:url	https://doi.org/10.1016/j.antiviral.2006.01.009
resource representing a document's title	Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference
has PubMed Central identifier	PMC7114231
has PubMed identifier	16530274
schema:publication	Antiviral Research
resource representing a document's body	covid:c4b8d416737b7b204d582699cab25f9b5eccc90b#body_text
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