About: Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration

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About: Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration
Creator	Russo, Lucia Affiliations, Vianello, Andrea Avogaro, Angelo Cattelan, Anna Fioretto, Paola Vettor, Roberto Bonora, Benedetta Arcidiacono, G Arcidiacono, Gaetano Avogaro, A Bonora, B Boscari, F Boscari, Federico Busetto, L Busetto, Luca Cattelan, A Costantini, G Costantini, Giorgia Fadini, Gian Fadini, Paolo Falaguasta, D Falaguasta, Daniele Farnia, F Farnia, Filippo Fioretto, P Ghirardini, F Ghirardini, Francesca Luca Morieri, Mario Maran, A Maran, Alberto Mazzocut, Sara Mazzocut, S Morieri, M Morieri, Mario Pinelli, S Pinelli, Silvia Russo, L Selmin, E Selmin, Elisa Tresso, S Tresso, Silvia Vettor, R Vianello, A Voltan, G Voltan, Giacomo
Source	Elsevier; Medline; PMC
abstract	Abstract Aims We investigated whether pre-existing diabetes, newly-diagnosed diabetes, and admission hyperglycemia were associated with COVID-19 severity independently from confounders. Methods We retrospectively analyzed data on patients with COVID-19 hospitalized between February and April 2020 in an outbreak hospital in North-East Italy. Pre-existing diabetes was defined by self-reported history, electronic medical records, or ongoing medications. Newly-diagnosed diabetes was defined by HbA1c and fasting glucose. The primary outcome was a composite of ICU admission or death. Results 413 subjects were included, 107 of whom (25.6%) had diabetes, including 21 newly-diagnosed. Patients with diabetes were older and had greater comorbidity burden. The primary outcome occurred in 37.4% of patients with diabetes compared to 20.3% in those without (RR 1.85; 95%C.I. 1.33-2.57; p<0.001). The association was stronger for newly-diagnosed compared to pre-existing diabetes (RR 3.06 vs 1.55; p=0.004). Higher glucose level at admission was associated with COVID-19 severity, with a stronger association among patients without as compared to those with pre-existing diabetes (interaction p<0.001). Admission glucose was correlated with most clinical severity indexes and its association with adverse outcome was mostly mediated by a worse respiratory function. Conclusion Newly-diagnosed diabetes and admission hyperglycemia are powerful predictors of COVID-19 severity due to rapid respiratory deterioration.
has issue date	2020-08-15(xsd:dateTime)
bibo:doi	10.1016/j.diabres.2020.108374
bibo:pmid	32805345
has license	els-covid
sha1sum (hex)	c503f392228bed7044030dd75d4bd41857ac6dd0
schema:url	https://doi.org/10.1016/j.diabres.2020.108374
resource representing a document's title	Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration
has PubMed Central identifier	PMC7428425
has PubMed identifier	32805345
schema:publication	Diabetes Research and Clinical Practice
resource representing a document's body	covid:c503f392228bed7044030dd75d4bd41857ac6dd0#body_text
is schema:about of	named entity 'respiratory' named entity 'hyperglycemia' named entity 'diabetes' named entity 'FPG' named entity 'diabetic patients' named entity 'organ damage' named entity 'diabetes' named entity 'hematology' named entity 'signs and symptoms' named entity 'diabetic' named entity 'eGFR' named entity 'diabetes' named entity 'probability' named entity 'diabetes' named entity 'social support' named entity 'stress hyperglycemia' named entity 'proportional hazard model' named entity 'organ damage' named entity 'COVID' named entity 'chronic kidney disease' named entity 'Poisson regression' named entity 'Statistical analyses' named entity '1.14' named entity 'glucocorticoids' named entity 'mediation analysis' named entity 'biochemical' named entity 'diabetes' named entity 'chronic medical condition' named entity 'diabetes' named entity 'oral anticoagulants' named entity 'antibiotics' named entity 'mechanical ventilation' named entity 'diabetes' named entity 'diabetes' named entity 'occult' named entity 'COVID'

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