About: Chitinase 3‐like 1 protein plays a critical role in respiratory syncytial virus‐induced airway inflammation

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About: Chitinase 3‐like 1 protein plays a critical role in respiratory syncytial virus‐induced airway inflammation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chitinase 3‐like 1 protein plays a critical role in respiratory syncytial virus‐induced airway inflammation
Creator	Yang, Mo Kim, Min Kim, Kyung Lee, Chun Lee, Jae Chang, \| Park, Han Sohn, Myung Elias, A Su, \| Hwang, Jin Cha, Hye-Ran Doo, \| Jack, \| Jeon, \| Moon, Kuk-Young Myung, \| Shim, Hee Sohn, Hyun
Source	Medline; PMC
abstract	BACKGROUND: Chitinase 3‐like 1 protein (CHI3L1) (YKL‐40 in humans and breast regression protein [BRP]‐39 in mice) is required for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma. However, the role of CHI3L1 in airway inflammation induced by respiratory viruses has not been investigated. The aim of this study was to investigate the relationship between CHI3L1 and airway inflammation caused by respiratory syncytial virus (RSV) infection. METHODS: We measured YKL‐40 levels in human nasopharyngeal aspirate (NPA) from hospitalized children presenting with acute respiratory symptoms. Wild‐type (WT) and BRP‐39 knockout (KO) C57BL/6 mice were inoculated with live RSV (A2 strain). Bronchoalveolar lavage fluid and lung tissue samples were obtained on day 7 after inoculation to assess lung inflammation, airway reactivity, and expression of cytokines and BRP‐39. RESULTS: In human subjects, YKL‐40 and IL‐13 levels in NPA were higher in children with RSV infection than in control subjects. Expression of BRP‐39 and Th2 cytokines, IL‐13 in particular, was increased following RSV infection in mice. Airway inflammation caused by RSV infection was reduced in BRP‐39 KO mice as compared to WT mice. Th2 cytokine levels were not increased in the lungs of RSV‐infected BRP‐39 KO mice. BRP‐39 regulated M2 macrophage activation in RSV‐infected mice. Additionally, treatment with anti‐CHI3L1 antibody attenuated airway inflammation and Th2 cytokine production in RSV‐infected WT mice. CONCLUSION: These findings suggest that CHI3L1 could contribute to airway inflammation induced by RSV infection. CHI3L1 could be a potential therapeutic candidate for attenuating Th2‐associated immunopathology during RSV infection.
has issue date	2018-12-04(xsd:dateTime)
bibo:doi	10.1111/all.13661
bibo:pmid	30402955
has license	no-cc
sha1sum (hex)	c55ffd0a07962fa75503b8b94d92f69b106be942
schema:url	https://doi.org/10.1111/all.13661
resource representing a document's title	Chitinase 3‐like 1 protein plays a critical role in respiratory syncytial virus‐induced airway inflammation
has PubMed Central identifier	PMC7159489
has PubMed identifier	30402955
schema:publication	Allergy
resource representing a document's body	covid:c55ffd0a07962fa75503b8b94d92f69b106be942#body_text
is schema:about of	named entity 'inflammation' named entity 'respiratory' named entity 'protein' named entity 'Chitinase' named entity 'inflammation' named entity 'protein' named entity 'caused' named entity 'RSV' named entity 'infection' named entity 'induced' named entity 'Th2' named entity 'inflammation' named entity 'Chitinase' named entity 'chronic inflammatory diseases' named entity 'respiratory syncytial virus (RSV) infection' named entity 'inflammation' named entity 'asthma' named entity 'protein' named entity 'airway' named entity 'RSV infection' named entity 'IL-13' named entity 'catheter' named entity 'pathogenesis' named entity 'RSV' named entity 'allergic inflammation' named entity 'inflammatory cytokines' named entity 'mucus production' named entity 'normal saline' named entity 'IL-5' named entity 'BALF' named entity 'Respiratory syncytial virus' named entity 'Muc5AC' named entity 'Th2' named entity 'coughing' named entity 'RSV' named entity 'cytokine' named entity 'RSV' named entity 'Applied Biosystems' named entity 'viral load' named entity 'RSV' named entity 'IL-5' named entity 'Student's t test' named entity 'mucus production' named entity 'asthma' named entity 'cytopathic effect' named entity 'RSV' named entity 'RSV' named entity 'lysates' named entity 'IL-13' named entity 'intraperitoneal' named entity 'IL-13' named entity 'PAS' named entity 'YKL-40' named entity 'inflammatory response' named entity 'YKL-40' named entity 'RSV infection' named entity 'gene' named entity 'IL-13' named entity 'mice' named entity 'RSV' named entity 'inflammation' named entity 'Th2' named entity 'plaque assay'

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