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About:
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
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schema:ScholarlyArticle
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
Creator
Ren, Lili
Wang, Jianwei
Xiang, Zichun
Chen, Ting
Guo, Li
Liu, Yan
Chen, Xing
Jin, Qi
Lei, Xiaobo
Qian, Zhaohui
Li, Pei
Mu, Zhixia
Ou, Xiuyuan
Mi, Dan
Chen, Jieyong
Guo, Ruixuan
Hu, Jiaxin
Hu, Keping
Source
Medline; PMC
abstract
Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients’ sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2.
has issue date
2020-03-27
(
xsd:dateTime
)
bibo:doi
10.1038/s41467-020-15562-9
bibo:pmid
32221306
has license
no-cc
sha1sum (hex)
c5db08a4925ae08d69530ee3c2bb263f8fd9fca4
schema:url
https://doi.org/10.1038/s41467-020-15562-9
resource representing a document's title
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
has PubMed Central identifier
PMC7100515
has PubMed identifier
32221306
schema:publication
Nat Commun
resource representing a document's body
covid:c5db08a4925ae08d69530ee3c2bb263f8fd9fca4#body_text
is
schema:about
of
named entity 'They'
named entity 'endocytosis'
named entity 'infect'
named entity 'remains'
named entity 'causative'
named entity 'analysis'
named entity 'emerged'
named entity 'glycoprotein'
covid:arg/c5db08a4925ae08d69530ee3c2bb263f8fd9fca4
named entity 'severe'
named entity 'outbreaks'
named entity 'SARS-CoV-2'
named entity 'SARS-CoV-2'
named entity 'protein'
named entity 'MERS-CoV'
named entity 'Yunnan'
named entity 'vaccines'
named entity 'nucleotide sequence'
named entity 'SARS-CoV-2'
named entity 'cave'
named entity 'SARS-CoV-2'
named entity 'stable'
named entity 'sequenced'
named entity 'virus'
named entity 'SARS'
named entity 'MERS-CoV'
named entity 'neurological diseases'
named entity 'China'
named entity 'zoonotic'
named entity 'zoonotic'
named entity 'Bat'
named entity 'SARS-CoV-2'
named entity 'dromedary camel'
named entity 'antibodies'
named entity 'SARS-CoV-2'
named entity 'SARS'
named entity 'MERS-CoV'
named entity 'MERS-CoV'
named entity 'SARS-CoV'
named entity 'PIKfyve'
named entity 'vaccines'
named entity 'protein'
named entity 'glycoprotein'
named entity 'SARS-CoV-2'
named entity 'enteric'
named entity 'MERS-CoV'
named entity 'virus'
named entity 'transduce'
named entity 'eGFP'
named entity 'protein'
named entity 'syncytia'
named entity '3,5'
named entity 'Addgene'
named entity 'SARS-CoV-2'
named entity 'protein'
named entity 'syncytium'
named entity 'apilimod'
named entity 'HeLa'
named entity 'MERS-CoV'
named entity 'TPC2'
named entity 'cytoplasmic'
named entity 'SARS-CoV-2'
named entity 'virus entry'
named entity 'SARS-CoV-2'
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