About: Estrogen shields women from COVID-19 complications by reducing ER stress

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Estrogen shields women from COVID-19 complications by reducing ER stress Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Estrogen shields women from COVID-19 complications by reducing ER stress
Creator	Khan, Muhammad Hafeez, Assad Khan, Jawad Muhammad, * Muhammad, Pakistan Rafiq, Arshad Rafiq, Muhammad Shabbir, Sana
Source	Elsevier; Medline; PMC
abstract	Estrogen hormone acts as a potential key player in providing immunity against certain viral infection. It is found to be associated in providing immunity against acute lungs inflammation and influenza virus by modulating cytokines storm and mediating adaptive immune alterations respectively. Women are less affected by SARS-CoV-2 infection because of the possible influence of estrogen hormone as compared to men. We hypothesized that SARS-CoV-2 causes stress in endoplasmic reticulum (ER) which in turn aggravates the infection, estrogen hormone might play key role in decreasing ER stress by activating estrogen mediated signaling pathways, results in unfolded protein response. Estrogen governs degradation of Phosphotidylinositol 4,5-Bisphosphate PIP(2) into diacylglycerol DAG and inositol triphosphate IP(3) with the help of phospholipase C. IP(3) start in-fluxing Ca(+2) ions that helps in UPR activation. To support our hypothesis, we analyzed the data of 162,392 COVID-19 patients to determine the relation of this disease with gender. We observed that 26% of women and 74% of men were affected by SARS-CoV-2. It indicated that women are less affected because of the possible influence of estrogen hormone in women.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.110148
bibo:pmid	32759016
has license	no-cc
sha1sum (hex)	c5ead785ea3afb329634d192e472e9c8ce5a313f
schema:url	https://doi.org/10.1016/j.mehy.2020.110148
resource representing a document's title	Estrogen shields women from COVID-19 complications by reducing ER stress
has PubMed Central identifier	PMC7390780
has PubMed identifier	32759016
schema:publication	Med Hypotheses
resource representing a document's body	covid:c5ead785ea3afb329634d192e472e9c8ce5a313f#body_text
is schema:about of	named entity 'hormone' named entity 'immunity' named entity 'reducing' named entity 'HORMONE' named entity 'IMMUNITY' named entity 'OUR' named entity 'ADAPTIVE' named entity 'MEN' named entity 'UNFOLDED PROTEIN RESPONSE' covid:arg/c5ead785ea3afb329634d192e472e9c8ce5a313f named entity 'Estrogen' named entity 'SARS-CoV-2' named entity 'infection' named entity 'COVID-19' named entity 'men' named entity 'Estrogen' named entity 'men' named entity 'estrogen' named entity 'hypothesis' named entity 'influence' named entity 'estrogen' named entity 'estrogen' named entity 'estrogen' named entity 'UPR' named entity 'cytokines' named entity 'lungs' named entity 'Estrogen' named entity 'Title Page' named entity 'COVID-19' named entity 'ER stress' named entity 'signaling pathways' named entity 'protein' named entity 'SRC-1' named entity 'UPR' named entity 'infection' named entity 'reperfusion injury' named entity 'UPR' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'unfolded protein response' named entity 'IRE1' named entity 'SARS-CoV-2' named entity 'Greece' named entity 'ATF6' named entity 'protein kinase' named entity 'protein modification' named entity 'SARS-CoV-2' named entity 'CFR' named entity 'XBP1' named entity 'Estrogen' named entity 'nonstructural proteins' named entity 'Death rate' named entity 'COVID-19' named entity 'inositol triphosphate' named entity 'kinase' named entity 'virus' named entity 'nonstructural proteins' named entity 'Coronavirus' named entity 'DMV' named entity 'ER stress' named entity 'infection' named entity 'Estrogen' named entity 'signaling pathway' named entity 'COVID' named entity 'China' named entity 'Estrogen' named entity 'virus' named entity 'receptor' named entity 'cytoplasm' named entity 'phospholipase' named entity 'UPR' named entity 'UPR' named entity 'spike protein' named entity 'single stranded RNA virus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software