About: Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor

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About: Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor
Creator	Okabayashi, Tamaki Fujii, Nobuhiro Tsutsumi, Hiroyuki Yokota, Shin-Ichi Hori, Tsukasa Yoto, Yuko
Source	Medline; PMC
abstract	Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. The platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae and Haemophilus influenzae, is upregulated by RSV infection in the pulmonary epithelial cell line A549. Fosfomycin, an antimicrobial agent, significantly suppressed PAF receptor induction by RSV infection at the mRNA and cell surface expression levels. Fosfomycin also suppressed RSV-induced adhesion of fluorescence-labeled S. pneumoniae and H. influenzae cells, as determined by flow cytometry and fluorescence microscopy. The RSV-induced bacterial adhesion was suggested to be host-PAF-receptor and bacterial-phosphocholine mediated. Fosfomycin, which has been shown to exhibit antimicrobial and immunomodulatory activities, was found here to suppress adhesion by disease-causing bacteria. Thus, fosfomycin might prevent secondary bacterial infection during RSV infection.
has issue date	2010-09-01(xsd:dateTime)
bibo:doi	10.1111/j.1574-6968.2010.02049.x
bibo:pmid	20629755
has license	no-cc
sha1sum (hex)	c63aa140f9708e77bf501b4cd79ba9bb282193aa
schema:url	https://doi.org/10.1111/j.1574-6968.2010.02049.x
resource representing a document's title	Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor
has PubMed Central identifier	PMC7110074
has PubMed identifier	20629755
schema:publication	FEMS Microbiol Lett
resource representing a document's body	covid:c63aa140f9708e77bf501b4cd79ba9bb282193aa#body_text
is schema:about of	named entity 'HAEMOPHILUS' named entity 'IS A' named entity 'FLUORESCENCE MICROSCOPY' named entity 'ANTIMICROBIAL AGENT' named entity 'LABELED' named entity 'HERE' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'ACUTE' named entity 'receptor' named entity 'expression' named entity 'infants' named entity 'platelet-activating factor' named entity 'respiratory tract' named entity 'S. pneumoniae' named entity 'BACTERIAL ADHESION' named entity 'IMMUNOMODULATORY' named entity 'EXHIBIT' named entity 'MEDIATED' named entity 'PULMONARY EPITHELIAL CELL' named entity 'FOSFOMYCIN' named entity 'VIRUS' named entity 'INDUCED' named entity 'RESPIRATORY' named entity 'ACTIVITIES' named entity 'PAF' named entity 'SUPPRESS' named entity 'SEVERE' named entity 'MRNA' named entity 'CELLS' named entity 'FLOW CYTOMETRY' named entity 'HOST' named entity 'INDUCED' named entity 'BACTERIA.' named entity 'LOWER RESPIRATORY TRACT' named entity 'RECEPTOR' named entity 'EPITHELIAL CELL LINE' named entity 'SUPPRESSES' named entity 'EPITHELIAL CELLS' named entity 'PLATELET-ACTIVATING FACTOR RECEPTOR' named entity 'FOSFOMYCIN' named entity 'PAF RECEPTOR' named entity 'PLATELET-ACTIVATING FACTOR' named entity 'INFANTS' named entity 'INDUCTION' named entity 'BACTERIAL' named entity 'LEVELS' named entity 'PREVENT' named entity 'DETERMINED BY' named entity 'UPREGULATED' named entity 'CAUSING' named entity 'HAEMOPHILUS INFLUENZAE' named entity 'ADHESION' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'DISEASE' named entity 'SUPPRESSED' named entity 'ANTIMICROBIAL' named entity 'FOUND' named entity 'EXPRESSION' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'FLUORESCENCE' named entity 'PHOSPHOCHOLINE' named entity 'RSV' named entity 'ILLNESS' named entity 'A549' named entity 'CAUSES' named entity 'ADHESION' named entity 'CELL SURFACE' named entity 'RSV INFECTION' named entity 'YOUNG CHILDREN' covid:arg/c63aa140f9708e77bf501b4cd79ba9bb282193aa named entity 'PAF' named entity 'severe' named entity 'H. influenzae' named entity 'Fosfomycin' named entity 'adhesion' named entity 'fluorescence'

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