About: MARs and MARBPs: Key modulators of gene regulation and disease manifestation

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About: MARs and MARBPs: Key modulators of gene regulation and disease manifestation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MARs and MARBPs: Key modulators of gene regulation and disease manifestation
Creator	Chattopadhyay, Samit Pavithra, Lakshminarasimhan
Source	PMC
abstract	The DNA in eukaryotic genome is compartmentalized into various domains by a series of loops tethered onto the base of nuclear matrix. Scaffold/ Matrix attachment regions (S/MAR) punctuate these attachment sites and govern the nuclear architecture by establishing chromatin boundaries. In this context, specific proteins that interact with and bind to MAR sequences called MAR binding proteins (MARBPs), are of paramount importance, as these sequences spool the proteins that regulate transcription, replication, repair and recombination. Recent evidences also suggest a role for these cis-acting elements in viral integration, replication and transcription, thereby affecting host immune system. Owing to the complex nature of these nucleotide sequences, less is known about the MARBPs that bind to and bring about diverse effects on chromatin architecture and gene function. Several MARBPs have been identified and characterized so far and the list is growing. The fact that most the MARBPs exist in a co-repressor/ co-activator complex and bring about gene regulation makes them quintessential for cellular processes. This participation in gene regulation means that any perturbation in the regulation and levels of MARBPs could lead to disease conditions, particularly those caused by abnormal cell proliferation, like cancer. In the present chapter, we discuss the role of MARs and MARBPs in eukaryotic gene regulation, recombination, transcription and viral integration by altering the local chromatin structure and their dysregulation in disease manifestation
has issue date	2007-01-01(xsd:dateTime)
bibo:doi	10.1007/1-4020-5466-1_10
has license	no-cc
sha1sum (hex)	c641b5f5a0ee928375b442b36d13336eb88198a9
schema:url	https://doi.org/10.1007/1-4020-5466-1_10
resource representing a document's title	MARs and MARBPs: Key modulators of gene regulation and disease manifestation
has PubMed Central identifier	PMC7121529
schema:publication	Chromatin and Disease
resource representing a document's body	covid:c641b5f5a0ee928375b442b36d13336eb88198a9#body_text
is schema:about of	named entity 'MAR' named entity 'eukaryotic' named entity 'nucleotide sequences' named entity 'cellular processes' named entity 'cell proliferation' named entity 'regulate transcription' named entity 'S/MAR' named entity 'recombination' named entity 'transcription' named entity 'gene regulation' named entity 'gene regulation' named entity 'gene regulation' named entity 'L-selectin' named entity 'chromatin' named entity 'nuclear matrix' named entity 'MAR' named entity 'ground substance' named entity 'organogenesis' named entity 'malignant' named entity 'CDK inhibitor' named entity 'LPS' named entity 'MeCP2' named entity 'Nuclear Matrix' named entity 'isoform' named entity 'p53' named entity 'gene expression' named entity 'intronic' named entity 'binding proteins' named entity 'chromatin structure' named entity 'melanoma' named entity 'MeCP2' named entity 'Cux' named entity 'SATB1' named entity 'retroviral integration' named entity 'neoplastic transformation' named entity 'HBV' named entity 'cell surface' named entity 'transcriptional' named entity 'gene' named entity 'Hainaut' named entity 'MARs' named entity 'binding protein' named entity 'IgH' named entity 'nuclear matrix' named entity 'isoforms' named entity 'tumorigenesis' named entity 'transcription elongation' named entity 'protein' named entity 'chromatin accessibility' named entity 'transforming growth factor beta' named entity 'chromatin structure' named entity 'cellular proliferation' named entity 'SATB1' named entity 'phenotype' named entity 'cancer cell' named entity 'chromatin' named entity 'chromatin' named entity 'activator protein' named entity 'cell cycle regulation' named entity 'co-activators' named entity 'cellular process' named entity 'transcription factor' named entity 'mitosis' named entity 'LCRs' named entity 'HDAC1' named entity 'derepressed' named entity 'chromatin' named entity 'MAR' named entity 'breast tumors' named entity 'gene expression' named entity 'DNaseI' named entity 'V(D)J recombination' named entity 'phenotype' named entity 'mitotic' named entity 'transgenic mice' named entity 'helical' named entity 'nuclear matrix' named entity 'chromatin domains' named entity 'bladder cancer' named entity 'SATB1' named entity 'transcription initiation' named entity 'nuclear matrix'

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