About: A cluster randomized clinical trial comparing fit‐tested and non‐fit‐tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers

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About: A cluster randomized clinical trial comparing fit‐tested and non‐fit‐tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A cluster randomized clinical trial comparing fit‐tested and non‐fit‐tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers
Creator	Zhang, Yi Seale, Holly Wang, Quanyi Yang, Peng Pang, Xinghuo Wang, Xiaoli Shi, Weixian Ferguson, Neil Rahman, Bayzidur Duan, Wei Cauchemez, Simon Gao, Zhanhai Chandini, Raina Dwyer, Dominic Macintyre,
Source	Medline; PMC
abstract	Please cite this paper as: MacIntyre et al. (2011) A cluster randomized clinical trial comparing fit‐tested and non‐fit‐tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2010.00198.x. Background We compared the efficacy of medical masks, N95 respirators (fit tested and non fit tested), in health care workers (HCWs). Methods A cluster randomized clinical trial (RCT) of 1441 HCWs in 15 Beijing hospitals was performed during the 2008/2009 winter. Participants wore masks or respirators during the entire work shift for 4 weeks. Outcomes included clinical respiratory illness (CRI), influenza‐like illness (ILI), laboratory‐confirmed respiratory virus infection and influenza. A convenience no‐mask/respirator group of 481 health workers from nine hospitals was compared. Findings The rates of CRI (3·9% versus 6·7%), ILI (0·3% versus 0·6%), laboratory‐confirmed respiratory virus (1·4% versus 2·6%) and influenza (0·3% versus 1%) infection were consistently lower for the N95 group compared to medical masks. By intention‐to‐treat analysis, when P values were adjusted for clustering, non‐fit‐tested N95 respirators were significantly more protective than medical masks against CRI, but no other outcomes were significant. The rates of all outcomes were higher in the convenience no‐mask group compared to the intervention arms. There was no significant difference in outcomes between the N95 arms with and without fit testing. Rates of fit test failure were low. In a post hoc analysis adjusted for potential confounders, N95 masks and hospital level were significant, but medical masks, vaccination, handwashing and high‐risk procedures were not. Interpretation Rates of infection in the medical mask group were double that in the N95 group. A benefit of respirators is suggested but would need to be confirmed by a larger trial, as this study may have been underpowered. The finding on fit testing is specific to the type of respirator used in the study and cannot be generalized to other respirators. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN: ACTRN12609000257268 (http://www.anzctr.org.au).
has issue date	2011-01-27(xsd:dateTime)
bibo:doi	10.1111/j.1750-2659.2011.00198.x
bibo:pmid	21477136
has license	no-cc
sha1sum (hex)	c657dee5652708f18918e1c24b24d2f98cc1c4af
schema:url	https://doi.org/10.1111/j.1750-2659.2011.00198.x
resource representing a document's title	A cluster randomized clinical trial comparing fit‐tested and non‐fit‐tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers
has PubMed Central identifier	PMC4941587
has PubMed identifier	21477136
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:c657dee5652708f18918e1c24b24d2f98cc1c4af#body_text
is schema:about of	named entity 'COMPARING' named entity 'N95' named entity 'N95' named entity 'comparing' named entity 'HEALTH CARE' named entity 'CLUSTER' named entity 'MASKS' named entity 'WORKERS' named entity 'TESTED' named entity 'RESPIRATORS' named entity 'HEALTH CARE' named entity 'NON' named entity 'NON-' named entity 'FIT' named entity 'COMPARED' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'TESTED' named entity 'MEDICAL' named entity 'TO PREVENT' named entity 'WORKERS' named entity 'BACKGROUND' named entity 'MEDICAL' named entity 'EFFICACY' named entity 'RESPIRATORS' named entity 'RANDOMIZED CLINICAL TRIAL' named entity 'MASKS' named entity 'N95' named entity 'N95' covid:arg/c657dee5652708f18918e1c24b24d2f98cc1c4af named entity 'medical' named entity 'compared' named entity 'fit-tested' named entity 'N95' named entity 'randomized clinical trial' named entity 'medical masks' named entity 'respiratory syncytial virus' named entity 'HKU1' named entity 'influenza' named entity 'sample size' named entity 'RCT' named entity 'respirator' named entity 'deionized water' named entity 'Medical masks' named entity 'randomization' named entity 'PCR amplification' named entity 'ILI' named entity 'STATA' named entity 'N95' named entity 'influenza' named entity 'medical masks' named entity 'fit testing' named entity 'laboratory tests' named entity 'MDCK' named entity 'virus' named entity 'respiratory symptom' named entity 'HCW' named entity 'high-risk' named entity 'high-risk' named entity 'rhinitis' named entity 'intubation' named entity 'SAS' named entity 'effect measure' named entity 'N95' named entity 'fit-tested' named entity 'serological' named entity 'influenza viruses' named entity 'pathogens'

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