About: Diversion of stress granules and P-bodies during viral infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Diversion of stress granules and P-bodies during viral infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Diversion of stress granules and P-bodies during viral infection
Creator	Lloyd, Richard Reineke, Lucas
source	Elsevier; Medline; PMC
abstract	Abstract RNA granules are structures within cells that impart key regulatory measures on gene expression. Two general types of RNA granules are conserved from yeast to mammals: stress granules (SGs), which contain many translation initiation factors, and processing bodies (P-bodies, PBs), which are enriched for proteins involved in RNA turnover. Because of the inverse relationship between appearance of RNA granules and persistence of translation, many viruses must subvert RNA granule function for replicative purposes. Here we discuss the viruses and mechanisms that manipulate stress granules and P-bodies to promote synthesis of viral proteins. Several themes have emerged for manipulation of RNA granules by viruses: (1) disruption of RNA granules at the mid-phase of infection, (2) prevention of RNA granule assembly throughout infection and (3) co-opting of RNA granule proteins for new or parallel roles in viral reproduction. Viruses must employ one or multiple of these routes for a robust and productive infection to occur. The possible role for RNA granules in promoting innate immune responses poses an additional reason why viruses must counteract the effects of RNA granules for efficient replication.
has issue date	2013-02-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.11.017
bibo:pmid	23290869
has license	els-covid
sha1sum (hex)	c65b00c6e7ef5ff3440a2c0ca5d5417317f365ce
schema:url	https://doi.org/10.1016/j.virol.2012.11.017
resource representing a document's title	Diversion of stress granules and P-bodies during viral infection
has PubMed Central identifier	PMC3611887
has PubMed identifier	23290869
schema:publication	Virology
resource representing a document's body	covid:c65b00c6e7ef5ff3440a2c0ca5d5417317f365ce#body_text
is schema:about of	named entity 'PBs' named entity 'RNA' named entity 'prevention' named entity 'turnover' named entity 'RNA' named entity 'conserved' named entity 'subvert' named entity 'granules' named entity 'additional' named entity 'Here' named entity 'inverse relationship' named entity 'infection' named entity 'poses' named entity 'RNA' named entity 'viral' named entity 'RNA' named entity 'viruses' named entity 'translation initiation' named entity 'RNA' named entity 'yeast' named entity 'viruses' named entity 'RNA' named entity 'infection' named entity 'Yellow Fever Virus' named entity 'AUG codon' named entity 'interferon' named entity 'NS5A' named entity 'viral DNA' named entity 'AGO1' named entity 'gene expression' named entity 'heptameric' named entity 'mutants' named entity 'viral RNA' named entity 'HCV' named entity 'phosphorylating' named entity 'polysome' named entity 'infection' named entity 'mRNA' named entity 'PBs' named entity 'transcriptional activation' named entity 'HCV' named entity 'hsp27' named entity 'kinase' named entity 'cytidine' named entity 'HCV' named entity 'transcriptional regulator' named entity 'stem loop' named entity 'eIF4A' named entity 'RNA' named entity 'gene regulation' named entity 'coronavirus' named entity 'plant cells' named entity 'RNA' named entity 'USP10' named entity 'translation initiation' named entity 'virus' named entity 'infection' named entity 'deadenylation' named entity 'eIF2a' named entity 'G3BP' named entity 'virus' named entity 'infection' named entity 'Junin virus' named entity 'viral replication' named entity 'eIF4A' named entity 'Poliovirus' named entity 'PBs' named entity 'virus' named entity 'West Nile virus' named entity 'cytoplasmic' named entity 'mRNA' named entity 'WNV' named entity 'viral proteins' named entity 'interferon' named entity 'gene expression' named entity 'WNV' named entity 'eIF2a' named entity 'eIF4E' named entity 'Deadenylation' named entity 'pathogen'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software