About: Hypermetabolism and COVID‐19

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hypermetabolism and COVID‐19
Creator	Bocchieri, Karl Cassiere, Hugh Derosa, Sarah Hartman, Alan Rt, Yar, Shiraz Yu, Jen Yu, Pey-Jen
source	Medline; PMC
abstract	BACKGROUND: Hypermetabolism has been described in stress states such as trauma, sepsis, ARDS, and severe burn injuries. We hypothesize that patients with COVID‐19 may develop a hypermetabolic state which may be a major contributing factor to the extraordinary ventilatory and oxygenation demands in patients with COVID‐19. METHOD: Resting energy expenditure (REE), carbon dioxide production (VCO2) and oxygen consumption (VO2) were measured by indirect calorimetry on seven critically ill patients with COVID‐19. RESULTS: The median measured REE was 4044 Kcal/day which was 235.7% ± 51.7% of predicted. The median VCO2 was 452 mL/min (range 295–582 mL/min) and the median VO2 was 585 mL/min (range 416–798 mL/min). CONCLUSION: Critically ill patients with COVID‐19 are in an extreme hypermetabolic state. This may explain the high failure rates for mechanical ventilation for these patients and highlights the potential need for increased nutritional requirements for such patients. This article is protected by copyright. All rights reserved
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1002/jpen.1948
bibo:pmid	32559309
has license	no-cc
sha1sum (hex)	c66b1d4256aebd950265bc64b204bb736a5ae0e8
schema:url	https://doi.org/10.1002/jpen.1948
resource representing a document's title	Hypermetabolism and COVID‐19
has PubMed Central identifier	PMC7323185
has PubMed identifier	32559309
schema:publication	JPEN J Parenter Enteral Nutr
resource representing a document's body	covid:c66b1d4256aebd950265bc64b204bb736a5ae0e8#body_text
is schema:about of	named entity 'Pey' named entity 'DEMANDS' named entity 'COVID-19' named entity 'sepsis' named entity 'COVID' named entity 'COVID-19' named entity 'REE' named entity 'kcal' named entity 'infection' named entity 'positive correlation' named entity 'ventilator settings' named entity 'hypoxic' named entity 'pO2' named entity 'COVID' named entity 'carbon dioxide' named entity 'lung injury' named entity 'C-reactive protein' named entity 'oxygen consumption' named entity 'acute respiratory failure' named entity 'hypoxia' named entity 'hypermetabolic state' named entity 'REE' named entity 'pCO2' named entity 'intravenous sedation' named entity 'indirect calorimetry' named entity 'resting energy expenditure' named entity 'inflammatory markers' named entity 'thoracostomy' named entity 'carbon dioxide' named entity 'Acute Respiratory Distress Syndrome' named entity 'case series' named entity 'Indirect calorimetry' named entity 'ECMO' named entity 'Pearson correlation coefficient' named entity 'case series' named entity 'indirect calorimetry' named entity 'COVID' named entity 'critically ill patients' named entity 'hypermetabolism' named entity 'ARDS' named entity 'Saint Paul, MN' named entity 'mmHg' named entity 'REE' named entity 'D-Dimer' named entity 'gas exchange' named entity 'Coronavirus disease 2019' named entity 'VO2' named entity 'Kcal' named entity 'REE' named entity 'mechanical ventilation' named entity 'mmHg' named entity 'COVID' named entity 'hypercapnia' named entity 'immune response' named entity 'ARDS' named entity 'metabolic' named entity 'COVID' named entity 'intubation' named entity 'renal replacement therapy' named entity 'CO2' named entity 'REE' named entity 'calories' named entity 'COVID' named entity 'REE' named entity 'hypermetabolism' named entity 'membrane oxygenator' named entity 'hypermetabolic state' named entity 'REE' named entity 'body weight' named entity 'severe burn injuries' named entity 'REE' named entity 'critically ill patients' named entity 'COVID' named entity 'COVID'

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