About: The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space
Creator	Lasecka, Lidia Baron, Michael Stewart, James
topic	covid:c6c0a0d35bdedb534df909619bd7f240f9d52ae6#this
source	PMC
abstract	Nairobi sheep disease virus (NSDV) of the genus Nairovirus causes a haemorrhagic gastroenteritis in sheep and goats with mortality up to 90%; the virus is found in East and Central Africa, and in India, where the virus is called Ganjam virus. NSDV is closely related to the human pathogen Crimean-Congo haemorrhagic fever virus, which also causes a haemorrhagic disease. As with other nairoviruses, replication of NSDV takes place in the cytoplasm and the new virus particles bud into the Golgi apparatus; however, the effect of viral replication on cellular compartments has not been studied extensively. We have found that the overall structure of the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment and the Golgi were unaffected by infection with NSDV. However, we observed that NSDV infection led to the loss of protein disulphide isomerase (PDI), an oxidoreductase present in the lumen of the endoplasmic reticulum (ER) and which assists during protein folding, from the ER. Further investigation showed that NSDV-infected cells have high levels of PDI at their surface, and PDI is also secreted into the culture medium of infected cells. Another chaperone from the PDI family, ERp57, was found to be similarly affected. Analysis of infected cells and expression of individual viral glycoproteins indicated that the NSDV PreGn glycoprotein is involved in redistribution of these soluble ER oxidoreductases. It has been suggested that extracellular PDI can activate integrins and tissue factor, which are involved respectively in pro-inflammatory responses and disseminated intravascular coagulation, both of which manifest in many viral haemorrhagic fevers. The discovery of enhanced PDI secretion from NSDV-infected cells may be an important finding for understanding the mechanisms underlying the pathogenicity of haemorrhagic nairoviruses.
has issue date	2014-04-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0094656
bibo:pmid	24714576
has license	cc-by
sha1sum (hex)	c6c0a0d35bdedb534df909619bd7f240f9d52ae6
schema:url	https://doi.org/10.1371/journal.pone.0094656
resource representing a document's title	The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space
has PubMed Central identifier	PMC3979861
has PubMed identifier	24714576
schema:publication	PLoS One
resource representing a document's body	covid:c6c0a0d35bdedb534df909619bd7f240f9d52ae6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c6c0a0d35bdedb534df909619bd7f240f9d52ae6
is schema:about of	named entity 'Oxidoreductases' named entity 'particles' named entity 'individual' named entity 'soluble' named entity 'EXTRACELLULAR SPACE' named entity 'NAIROBI SHEEP DISEASE VIRUS' named entity 'CHAPERONE' named entity 'OXIDOREDUCTASES' named entity 'OVERALL' named entity 'VIRAL REPLICATION' named entity 'OBSERVED' named entity 'PDI' named entity 'DISULPHIDE' named entity 'ISOMERASE' named entity 'CELL SURFACE' named entity 'GLYCOPROTEINS' named entity 'HAVE' named entity 'LUMEN' covid:arg/c6c0a0d35bdedb534df909619bd7f240f9d52ae6 named entity 'VIRAL' named entity 'PATHOGENICITY' named entity 'BARON' named entity 'MAY BE' named entity 'ERP57' named entity 'MORTALITY' named entity 'WHERE' named entity 'ACTIVATE' named entity 'PRESENT' named entity 'FOUND' named entity 'MECHANISMS' named entity 'PATHOGEN' named entity 'HAEMORRHAGIC' named entity 'AFFECTED' named entity 'INFECTION' named entity 'STRUCTURE' named entity 'UP TO' named entity 'CELL SURFACE' named entity 'LIKE' named entity 'VIRUS' named entity 'ENHANCED' named entity 'PRO-INFLAMMATORY RESPONSES' named entity 'CITATION' named entity 'ASSISTS' named entity 'NAIROVIRUSES' named entity 'DISSEMINATED INTRAVASCULAR COAGULATION' named entity 'INDIVIDUAL' named entity 'IMPORTANT' named entity 'ENDOPLASMIC RETICULUM' named entity 'CELLULAR' named entity 'GOLGI' named entity 'THEIR' named entity 'PROTEIN ' named entity 'PROTEIN ' named entity 'ENDOPLASMIC RETICULUM' named entity 'THE CELL' named entity 'ER-GOLGI INTERMEDIATE COMPARTMENT' named entity 'TISSUE FACTOR' named entity 'DISULPHIDE' named entity 'NAIROVIRUS' named entity 'ANALYSIS' named entity 'CENTRAL AFRICA' named entity 'HIGH' named entity 'UNAFFECTED' named entity 'EXTRACELLULAR' named entity 'SHEEP' named entity 'HUMAN' named entity 'SOLUBLE' named entity 'DISCOVERY' named entity 'SECRETED' named entity 'COMPARTMENTS' named entity 'RELATED' named entity 'NEW' named entity 'UNDERLYING' named entity 'EXPRESSION' named entity 'REPLICATION' named entity 'TRANSLOCATION' named entity 'INVOLVED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software