About: Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?
Creator	Hoppe, Uta Egle, · Lichtenauer, · Lukas, · Motloch, J Paar, Vera Wernly, · Zhou, Zhichao
Source	Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a higher risk of mortality compared to influenza, which is mainly due to severe secondary diseases, such as acute respiratory distress syndrome (ARDS). In turn, ARDS is characterized by an acute inflammation and an excessive activity of the coagulation cascade, rising the vulnerability for venous thromboembolic events. In order to investigate the relation of inflammation and the influence of coagulation factors on their release, human peripheral mononuclear blood cells (PBMCs) were treated with autologous serum, heparinized plasma and different doses of fibrin. Thereafter, the concentration of pro-inflammatory cytokines and chemokines in the secretome of PBMCs was measured by enzyme-linked immunosorbent assay. Our analyses revealed autologous serum to significantly increase the secretion of cytokines and chemokines after 24 h of incubation time. Furthermore, the addition of fibrin markedly increased the secretion of cytokines and chemokines by PBMCs in a dose-dependent manner. Consequently, in accordance with previous studies, our study outlines that anti-coagulation may constitute a promising tool for the treatment of SARS-CoV-2, reducing both, the cytokine storm, as well as the risk for thrombotic complications.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1007/s11239-020-02212-6
bibo:pmid	32632558
has license	cc-by
sha1sum (hex)	c6cb07d9e3254ec7c5bb37e2fe855fc5900ead6c
schema:url	https://doi.org/10.1007/s11239-020-02212-6
resource representing a document's title	Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?
has PubMed Central identifier	PMC7338133
has PubMed identifier	32632558
schema:publication	J Thromb Thrombolysis
resource representing a document's body	covid:c6cb07d9e3254ec7c5bb37e2fe855fc5900ead6c#body_text
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