About: Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya
Creator	Shi, Zheng-Li Li, Bei Yang, Xing-Lou Zheng, Xiao-Shuang Canuti, Marta Agwanda, Bernard Fan, Yi Hu, Ben Kering, Kelvin Obanda, Vincent Ommeh, Sheila Megid, Jane Li, Hu Onyuok, Samson Kroon, Erna Go, Ochola Ochieng Ochola, Griphin So, Onyuok
source	Medline; PMC
abstract	The majority of emerging and reemerging zoonotic viral pathogens are RNA viruses. Pathogen discovery programs of emerging infectious diseases (EIDs) in wildlife have implicated rodents and shrews as hosts of diverse human pathogens, such as hantaviruses, arenaviruses, paramyxoviruses, etc. Despite these threats, little is known about the diversity of viruses circulating among rodents and shrews in Kenya, meaning the risk of infectious disease outbreak from these small mammals could be oblivious. This study reports the first surveillance toward understanding the diversity of RNA viruses carried by rodents and shrews in areas of high-potential contact with humans in Kenya through molecular detection. A total of 617 samples comprising fecal, urine, and tissues from 138 rodents and 5 shrews were screened for eight different families of viruses using RT-PCR assays. The results highlight the presence of diverse astroviruses, paramyxoviruses, hepeviruses, and arenavirus, circulating in both wild and synanthropic Kenyan rodents and shrews. Most of the viruses detected in this study are novel strains and some belong to the families that contain important human viral pathogens. Notably, a novel arenavirus was detected in Grammomys macmillani, a rodent species newly identified to harbor arenavirus, and it potentially represent a novel arenavirus species. Our findings demonstrate the need for continued pathogen surveillance among these small mammals as well as among the vulnerable and exposed livestock and humans. This would help in development and implementation of effective preventive and control strategies on EIDs in countries with rich wildlife biodiversity like Kenya.
has issue date	2019-11-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02696
bibo:pmid	31824465
has license	cc-by
sha1sum (hex)	c6ee9f876eedfbe7aa60473dcad1e8fcdc4c3a2d
schema:url	https://doi.org/10.3389/fmicb.2019.02696
resource representing a document's title	Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya
has PubMed Central identifier	PMC6881279
has PubMed identifier	31824465
schema:publication	Front Microbiol
resource representing a document's body	covid:c6ee9f876eedfbe7aa60473dcad1e8fcdc4c3a2d#body_text
is schema:about of	named entity 'Kenya' named entity 'Viruses' named entity 'RNA VIRUSES' named entity 'RODENTS' named entity 'KENYA' named entity 'NOVEL' named entity 'DETECTION' named entity 'WILD' named entity 'SHREWS' named entity 'MOLECULAR' named entity 'GENETIC CHARACTERIZATION' named entity 'Genetic' named entity 'Synanthropic' named entity 'liver' named entity 'rodent' named entity 'Ippy' named entity 'coding sequences' named entity 'kidney' named entity 'Nucleotide sequences' named entity 'ClustalW' named entity 'spleen' named entity 'rat' named entity 'sequence identity' named entity 'Kenya' named entity 'ketamine' named entity 'virus' named entity 'Line transects' named entity 'Mopeia' named entity 'viruses' named entity 'natural reservoir' named entity 'natural reservoir' named entity 'DNAstar' named entity 'genome sequence' named entity 'liver' named entity 'virus' named entity 'viral shedding' named entity 'United States' named entity 'kidney' named entity 'gastroenteritis' named entity 'Southern Africa' named entity 'Kenya' named entity 'intramuscular injection' named entity 'rat' named entity 'R. rattus' named entity 'Kitale' named entity 'rodents' named entity 'zoonotic pathogens' named entity 'virus' named entity 'flavivirus' named entity 'host species' named entity 'Lambeth' named entity 'Ippy' named entity 'rodent' named entity 'shrew' named entity 'Central Africa' named entity 'paramyxoviruses' named entity 'field work' named entity 'RdRp' named entity 'virus' named entity 'gene' named entity 'virus' named entity 'Kitale' named entity 'infection' named entity 'Orthohepevirus'

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