About: Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection
Creator	Horvat, Branka Mathieu, Cyrille Raoul, Hervé Dhondt, Kévin Chalons, Marie Reynaud, Joséphine Vallve, Audrey
source	Medline; PMC
abstract	Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are resistant to henipavirus infection. We report here the susceptibility of mice deleted for the type I interferon receptor (IFNAR-KO) to both HeV and NiV. Intraperitoneally infected mice developed fatal encephalitis, with pathology and immunohistochemical features similar to what was found in humans. Viral RNA was found in the majority of analyzed organs, and sublethally infected animals developed virus-specific neutralizing antibodies. Altogether, these results reveal IFNAR-KO mice as a new small animal model to study HeV and NiV pathogenesis, prophylaxis, and treatment and suggest the critical role of type I interferon signaling in the control of henipavirus infection.
has issue date	2013-01-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jis653
bibo:pmid	23089589
has license	no-cc
sha1sum (hex)	c6f334ca4f0a0d66bdf07cd01cb2059432446147
schema:url	https://doi.org/10.1093/infdis/jis653
resource representing a document's title	Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection
has PubMed Central identifier	PMC7107294
has PubMed identifier	23089589
schema:publication	J Infect Dis
resource representing a document's body	covid:c6f334ca4f0a0d66bdf07cd01cb2059432446147#body_text
is schema:about of	named entity 'humans' named entity 'organs' named entity 'majority' named entity 'developed' named entity 'animal model' named entity 'HENIPAVIRUS INFECTION' named entity 'RECENTLY' named entity 'VIRUS ENTRY' named entity 'CRITICAL' named entity 'FUNCTIONAL' named entity 'INFECTED' named entity 'ENCEPHALITIS' named entity 'RECEPTORS' named entity 'CONTRAST' named entity 'HUMANS' named entity 'CAUSING' named entity 'SMALL ANIMAL' named entity 'DELETED' named entity 'VIRUS' covid:arg/c6f334ca4f0a0d66bdf07cd01cb2059432446147 named entity 'GENUS' named entity 'TYPE I INTERFERON' named entity 'SPECIES' named entity 'PROPHYLAXIS' named entity 'INTERFERON SIGNALING' named entity 'MICE' named entity 'LETHAL' named entity 'PARAMYXOVIRUSES' named entity 'IFNAR' named entity 'NEW' named entity 'THESE' named entity 'HEV' named entity 'PATHOGENESIS' named entity 'INCLUDING' named entity 'ORGANS' named entity 'REPORT' named entity 'MICE' named entity 'CONSIDERABLE' named entity 'NIPAH VIRUS' named entity 'FEATURES' named entity 'TYPE I INTERFERON' named entity 'ROLE' named entity 'CONTROL' named entity 'MAJORITY' named entity 'HENIPAVIRUS INFECTION' named entity 'HERE' named entity 'CAPABLE' named entity 'HENIPAVIRUS' named entity 'SUSCEPTIBILITY' named entity 'NUMBER OF' named entity 'HENDRA VIRUS' named entity 'EXPRESSION' named entity 'STUDY' named entity 'RESISTANT TO' named entity 'ANIMAL MODEL' named entity 'RELATED' named entity 'TREATMENT' named entity 'FOUND' named entity 'VIRAL RNA' named entity 'NIV' named entity 'ANALYZED' named entity 'RESULTS' named entity 'SIMILAR' named entity 'SUGGEST' named entity 'PATHOLOGY' named entity 'WHAT' named entity 'NEUTRALIZING ANTIBODIES' named entity 'SPECIFIC' named entity 'REVEAL' named entity 'FORM' named entity 'INTERFERON SIGNALING' named entity 'ANIMALS' named entity 'MORBIDITY AND MORTALITY' named entity 'FATAL' named entity 'TYPE I INTERFERON RECEPTOR'

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