About: A role for the Clostridium perfringens β2 toxin in bovine enterotoxaemia?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A role for the Clostridium perfringens β2 toxin in bovine enterotoxaemia?
Creator	Coppe, P Daube, G Detilleux, J Ginter, A Jauniaux, T Kaeckenbeeck, A Linden, A Manteca, C Pirson, V Mainil, J
source	Elsevier; Medline; PMC
abstract	Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the α toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described β2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringens isolated from 133 calves with lesions of enterotoxaemia and high clostridial cell counts (study population) and 386 isolated from a control population of 87 calves were tested by a colony hybridisation assay for the β2 toxin. Two hundred and eighteen (31%) C. perfringens isolated from 83 calves (62%) of the study population and 113 (29%) C. perfringens isolated from 51 calves (59%) of the control population tested positive with the β2 probe. Pure and mixed cultures of four C. perfringens (one α+β2+, one α+enterotoxin+ and two α+) were tested in the ligated loop assay in one calf. Macroscopic haemorrhages of the intestinal wall, necrosis and haemorrhages of the intestinal content, and microscopic lesions of necrosis and polymorphonuclear and mononuclear cell infiltration of the intestinal villi were more pronounced in loops inoculated with the α and β2-toxigenic C. perfringens isolate. These results suggest in vivo synergistic role of the α and β2 toxins in the production of necrotic and haemorrhagic lesions of the small intestine in cases of bovine enterotoxaemia. However, isolation of β2-toxigenic C. perfringens does not confirm the clinical diagnosis of bovine enterotoxaemia and a clostridial cell counts must still be performed.
has issue date	2002-05-01(xsd:dateTime)
bibo:doi	10.1016/s0378-1135(02)00008-1
bibo:pmid	11900954
has license	no-cc
sha1sum (hex)	c704ccda827e52e541d28f8660cdf90caf7ecaa6
schema:url	https://doi.org/10.1016/s0378-1135%2802%2900008-1
resource representing a document's title	A role for the Clostridium perfringens β2 toxin in bovine enterotoxaemia?
has PubMed Central identifier	PMC7117356
has PubMed identifier	11900954
schema:publication	Vet Microbiol
resource representing a document's body	covid:c704ccda827e52e541d28f8660cdf90caf7ecaa6#body_text
is schema:about of	named entity 'intestinal villi' named entity 'lesions' named entity 'C. perfringens' named entity 'population' named entity 'fourteen' named entity 'population' named entity 'haemorrhages' covid:arg/c704ccda827e52e541d28f8660cdf90caf7ecaa6 named entity 'type A' named entity 'microscopic' named entity 'type A' named entity 'Clostridium' named entity 'colony' named entity 'C. perfringens' named entity 'calves' named entity 'content' named entity 'small intestine' named entity 'control' named entity 'necrotic' named entity 'toxigenic' named entity 'necrosis' named entity 'small intestine' named entity 'Microbiology' named entity 'cell counts' named entity 'synergistic' named entity 'clinical diagnosis' named entity 'assay' named entity 'haemorrhagic' named entity 'bovine' named entity 'toxin' named entity 'intestinal content' named entity 'C. perfringens' named entity 'enteritis' named entity 'enterotoxigenic' named entity 'toxin' named entity 'C. perfringens' named entity 'haemorrhages' named entity 'Clostridium perfringens' named entity 'C. perfringens' named entity 'bovine' named entity 'C. perfringens' named entity 'enterotoxin' named entity 'liver' named entity 'macroscopic' named entity 'necrosis' named entity 'toxin' named entity 'enterotoxaemia' named entity 'intestinal villi' named entity 'necrotic' named entity 'toxin' named entity 'C. perfringens' named entity 'toxin' named entity 'sandwich ELISA' named entity 'enterotoxaemia' named entity 'body temperature' named entity 'Cs2' named entity 'toxin' named entity 'Salmonella' named entity 'immune sera' named entity 'C. perfringens' named entity 'enteritis' named entity 'enterotoxaemia' named entity 'Histologically' named entity 'necrotic' named entity 'inocula' named entity 'coronavirus' named entity 'small intestine' named entity 'C. perfringens' named entity 'Cb2' named entity 'study population' named entity 'haemorrhagic' named entity 'radioactively labelled'

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