About: The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

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About: The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription
Creator	Canard, Bruno Coutard, Bruno Ferron, François Frangeul, Antoine Jamal, Saïd Kerber, Romy Lelke, Michaela Lescar, Julien Morin, Benjamin Vonrhein, Clemens De Lamballerie, Xavier Charrel, Ré Cé Cile Baronti, Gü Nther, Stephan Rard Bricogne, Gé
Source	Medline; PMC
abstract	Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a ‘cap-snatching’ mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arenavirus: lymphocytic choriomeningitis virus. The NL1 domain is able to bind and cleave RNA. The 2.13 Å resolution crystal structure of NL1 reveals a type II endonuclease α/β architecture similar to the N-terminal end of the influenza virus PA protein. Superimposition of both structures, mutagenesis and reverse genetics studies reveal a unique spatial arrangement of key active site residues related to the PD…(D/E)XK type II endonuclease signature sequence. We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease.
has issue date	2010-09-16(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1001038
bibo:pmid	20862324
has license	cc-by
sha1sum (hex)	c73aa8452ccd63758df52737aae67450f078e76b
schema:url	https://doi.org/10.1371/journal.ppat.1001038
resource representing a document's title	The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription
has PubMed Central identifier	PMC2940758
has PubMed identifier	20862324
schema:publication	PLoS Pathog
resource representing a document's body	covid:c73aa8452ccd63758df52737aae67450f078e76b#body_text
is schema:about of	named entity 'N-TERMINAL ' named entity 'transcripts' named entity 'crystal structure' named entity 'reveal' named entity 'PROTEIN ' named entity 'MRNA TRANSCRIPTION' named entity 'HERE' named entity 'ARRANGEMENT' named entity 'ACTIVE' named entity 'STUDIES' named entity 'CAP' named entity 'ESSENTIAL' named entity 'PROTEIN ' named entity 'NL1' named entity 'INFLUENZA VIRUS' named entity 'CHARACTERIZATION' named entity 'STRUCTURES' named entity 'ARENAVIRUS' named entity 'CITATION' named entity 'MRNAS' named entity 'SHORT' named entity 'CAPPED' named entity 'BIND' named entity 'DOMAIN' named entity 'REVEALS' named entity 'SUPERIMPOSITION' named entity 'SYNTHESIZE' named entity 'ORTHOMYXOVIRIDAE' named entity 'MUTAGENESIS' named entity 'UNIQUE' named entity 'SIMILAR' named entity 'RNA' named entity 'N-TERMINAL ' named entity '2FB' named entity 'KEY' named entity 'LYMPHOCYTIC CHORIOMENINGITIS VIRUS' named entity 'TRANSCRIPTS' named entity 'FERRON' named entity 'VIRUS' named entity 'ARCHITECTURE' named entity 'FUNCTIONAL' named entity 'ACTIVE SITE' named entity 'VIRAL' named entity 'ACROSS' named entity 'BUNYAVIRIDAE' named entity 'SEQUENCE' named entity 'ENDONUCLEASE' named entity 'ESSENTIAL' named entity 'ARENAVIRUS' named entity 'RNA' named entity 'RELATED' named entity 'CELLULAR' named entity 'FAMILIES' named entity 'PRIMERS' named entity 'PROTEIN' named entity 'ARENAVIRIDAE' named entity '196' named entity 'ENDONUCLEASE' named entity 'REVERSE GENETICS' named entity 'SIGNATURE' named entity 'TYPE II' named entity 'REPORT' named entity 'END' named entity 'SPATIAL' named entity 'ACQUIRED' named entity 'MORIN' named entity 'DOMAIN'

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