About: Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial
Creator	Kacmarek, Robert Gómez-Zamora, Ana Villar, Jesus De La Oliva, P Gómez-Zamora, Á Kacmarek, R Oliva, La Schüffelmann, Á Villar, J
Source	PMC
abstract	PURPOSE: To determine if neurally adjusted ventilatory assist (NAVA) improves asynchrony, ventilatory drive, breath-to-breath variability and COMFORT score when compared to pressure support (PS). METHODS: This is a non-randomized short-term cross-over trial in which 12 pediatric patients with asynchrony (auto-triggering, double triggering or non-triggered breaths) were enrolled. Four sequential 10-min periods of data were recorded after 20 min of ventilatory stabilization (wash-out) at each of the following settings: baseline PS with the ventilator settings determined by the attending physician (1-PS(b)); PS after optimization (2-PS(opt)); NAVA level set so that maximum inspiratory pressure (P (max)) equaled P (max) in PS (3-NAVA); same settings as in 2-PS(opt) (4-PS(opt)). RESULTS: The median asynchrony index was significantly lower during NAVA (2.0 %) than during 2-PS(opt) (8.5 %, p = 0.017) and 4-PS(opt) (7.5 %, p = 0.008). In NAVA mode, the NAVA trigger accounted on average for 66 % of triggered breaths. The median trigger delay with respect to neural inspiratory time was significantly lower during NAVA (8.6 %) than during 2-PS(opt) (25.2 %, p = 0.003) and 4-PS(opt) (28.2 %, p = 0.0005). The median electrical activity of the diaphragm (EAdi) change during trigger delay normalized to maximum inspiratory EAdi difference was significantly lower during NAVA (5.3 %) than during 2-PS(opt) (21.7 %, p = 0.0005) and 4-PS(opt) (24.6 %, p = 0.001). The coefficient of variation of tidal volume was significantly higher during NAVA (44.2 %) than during 2-PS(opt) (19.8 %, p = 0.0002) and 4-PS(opt) (23.0 %, p = 0.0005). The median COMFORT score during NAVA (15.0) was lower than that during 2-PS(opt) (18.0, p = 0.0125) and 4-PS(opt) (17.5, p = 0.039). No significant changes for any variable were observed between 1-PS(b) and 2-PS(opt). CONCLUSIONS: Neurally adjusted ventilatory assist as compared to optimized PS results in improved synchrony, reduced ventilatory drive, increased breath-to-breath mechanical variability and improved patient comfort. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-012-2535-y) contains supplementary material, which is available to authorized users.
has issue date	2012-04-06(xsd:dateTime)
bibo:doi	10.1007/s00134-012-2535-y
bibo:pmid	22481227
has license	no-cc
sha1sum (hex)	c74fefa0d284f1418654db6b8099740d69d019f8
schema:url	https://doi.org/10.1007/s00134-012-2535-y
resource representing a document's title	Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial
has PubMed Central identifier	PMC7094903
has PubMed identifier	22481227
schema:publication	Intensive Care Med
resource representing a document's body	covid:c74fefa0d284f1418654db6b8099740d69d019f8#body_text
is schema:about of	named entity 'reduced' named entity 'NAVA' named entity 'maximum' named entity 'DIFFERENCE' named entity 'PRESSURE SUPPORT' named entity 'CROSS-OVER TRIAL' named entity 'HIGHER' named entity 'ADJUSTED' named entity 'ENROLLED' named entity 'MAX' named entity 'COMFORT' named entity 'PEDIATRIC' named entity '0.003' named entity 'NON-' named entity 'SET' named entity '287' named entity 'IMPROVED' named entity '008' named entity 'MECHANICAL' named entity 'SHORT-TERM' named entity 'PERIODS' named entity 'PURPOSE' named entity 'RESULTS' named entity 'TIDAL VOLUME' named entity 'NORMALIZED' named entity 'LOWER' named entity 'NAVA' named entity 'determined' named entity 'higher' named entity 'tidal volume' named entity 'stabilization' named entity 'variation' named entity 'attending physician' named entity 'periods' named entity 'NAVA' named entity 'drive' named entity 'comfort' named entity 'median' named entity 'median' named entity 'pediatric' named entity 'coefficient of variation' named entity 'NAVA' named entity 'tidal volume' named entity 'NAVA' named entity 'neurally adjusted ventilatory assist' named entity 'NAVA' named entity 'pediatric patients' named entity 'NAVA' named entity 'NAVA' named entity 'mechanically ventilated' named entity 'respiration' named entity 'attending physician' named entity 'NAVA' named entity 'NAVA' named entity 'ventilator' named entity 'mechanical ventilation' named entity 'effect size' named entity 'PEEP' named entity 'NAVA' named entity 'NAVA' named entity 'NAVA' named entity 'NAVA' named entity 'sedation' named entity 'analgesia' named entity 'electromyogram' named entity 'sedation' named entity 'sedation' named entity 'NAVA' named entity 'mechanically ventilated' named entity 'NAVA' named entity 'NAVA' named entity 'Confidence limits' named entity 'NAVA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software