About: Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

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About: Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
Creator	Le Pendu, Jacques Smith, David Czako, Rita Hu, Liya Cortes-Penfield, Nicolas Crawford, Sue Estes, Mary Mclean, Marrs Venkataram Prasad, B
Source	Medline; PMC
abstract	As with many other viruses, the initial cell attachment of rotaviruses, major causative agent of infantile gastroenteritis, is mediated by interactions with specific cellular glycans(1–4). The distally located VP8* domain of the rotavirus spike protein VP4(5) mediates such interactions. The existing paradigm is that ‘sialidase-sensitive’ animal rotavirus strains bind to glycans with terminal sialic acid (Sia), whereas ‘sialidase-insensitive’ human rotavirus (HR) strains bind to glycans with internal Sia such as GM1(3). Although the involvement of Sia in the animal strains is firmly supported by crystallographic studies(1,3,6,7), it is not yet known how VP8* of HRs interacts with Sia and whether their cell attachment necessarily involves sialoglycans. We found that VP8* of a HR strain specifically recognizes A-type histo-blood group antigen (HBGA) using a glycan array screen comprised of 511 glycans, and that virus infectivity in HT-29 cells is abrogated by anti-Atype antibodies as well as significantly enhanced in CHO cells genetically modified to express the A-type HBGA, providing a novel paradigm for initial cell attachment of HR. HBGAs are genetically determined glycoconjugates present in mucosal secretions, epithelial and on red blood cells(8), and are recognized as susceptibility and cell attachment factors for gastric pathogens like H. pylori(9) and noroviruses(10). Our crystallographic studies show that the A-type HBGA binds to the HR VP8* at the same location as the Sia in the VP8* of animal rotavirus, and suggest how subtle changes within the same structural framework allow for such receptor switching. These results raise the possibility that host susceptibility to specific HR strains and pathogenesis are influenced by genetically controlled expression of different HBGAs among the world’s population.
has issue date	2012-04-15(xsd:dateTime)
bibo:doi	10.1038/nature10996
bibo:pmid	22504179
has license	no-cc
sha1sum (hex)	c7bc90f329faeba483338d68f8cda2b59506da57
schema:url	https://doi.org/10.1038/nature10996
resource representing a document's title	Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
has PubMed Central identifier	PMC3350622
has PubMed identifier	22504179
schema:publication	Nature
resource representing a document's body	covid:c7bc90f329faeba483338d68f8cda2b59506da57#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'viruses' named entity 'HT-29' named entity 'supported' named entity 'advice' named entity 'diffraction' named entity 'parental' named entity 'ANALYZED' named entity 'PHONE' named entity 'COM' named entity 'STRUCTURAL DATA' named entity 'HT-29' named entity 'STRUCTURE DETERMINATION' named entity 'THEIR' named entity 'HTML' named entity 'INITIAL CELL' named entity 'SUBJECT' named entity '798' named entity 'FIRMLY' named entity 'NOVEL' named entity 'HBGA' named entity 'INFANTILE GASTROENTERITIS' named entity 'INVOLVEMENT' named entity 'ACCESS' named entity 'CARRIED' named entity 'INTERACTIONS' named entity 'CAUSATIVE AGENT' named entity 'FOUND' named entity '5686' named entity 'CELL ATTACHMENT' named entity 'HUMAN ROTAVIRUS' named entity 'HHS' named entity 'TYPE' named entity 'EXPRESSION' named entity 'ANALYSIS' named entity 'MAJOR' named entity 'MANUSCRIPT' named entity 'PROVIDING' named entity 'SUPPORTED' named entity 'MEDIATED' named entity 'RESEARCH' named entity 'SPIKE PROTEIN' named entity 'USE' named entity 'MAY VIEW' named entity 'HEMAGGLUTINATION' named entity 'DATA ANALYSES' named entity 'BLOOD GROUP ANTIGEN' named entity 'ANTIBODIES' named entity 'TO EXPRESS' named entity 'PROVIDED' named entity 'SENSITIVE' named entity 'PARENTAL' named entity 'VIRUS INFECTIVITY' named entity 'OVERALL' named entity 'KNOWN' named entity 'ADVICE' named entity 'STRAINS' named entity 'CELL ATTACHMENT' named entity 'ON CELL' named entity 'INTERNAL' named entity 'BLOOD GROUP ANTIGEN' named entity 'TMC' named entity 'NATURE' named entity 'CONTENT' named entity 'POLICIES' named entity 'ROTAVIRUS' named entity 'CONDITIONS' named entity 'HOW' named entity 'PUBLIC' named entity 'TYPE' named entity 'CHO CELLS' named entity 'TERMINAL' named entity 'STRAIN'

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