About: Molecular Epidemiology of Severe Acute Respiratory Syndrome–Associated Coronavirus Infections in Taiwan

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Epidemiology of Severe Acute Respiratory Syndrome–Associated Coronavirus Infections in Taiwan
Creator	Liu, Hsin-Fu Chan, Yu-Jiun Hsiung, Chao Yang, Jyh-Yuan Lan, Yu-Ching Ho, Mei-Shang Chen, Hour-Young Chen, Yi-Ming Lu, Jang-Jih Chen, Yen-Ju Hsiao, Kwang-Jen Lee, Cheng-Ming Liu, Tze-Tze
Source	Medline; PMC
abstract	Background In 2003, Taiwan experienced a series of outbreaks of severe acute respiratory syndrome (SARS) and 1 laboratory-contamination accident. Here we describe a new phylogenetic analytical method to study the sources and dissemination paths of SARS-associated coronavirus (SARS-CoV) infections in Taiwan Methods A phylogenetic analytical tool for combining nucleotide sequences from 6 variable regions of a SARS-CoV genome was developed by use of 20 published SARS-CoV sequences; and this method was validated by use of 80 published SARS-CoV sequences. Subsequently, this new tool was applied to provide a better understanding of the entire complement of Taiwanese SARS-CoV isolates, including 20 previously published and 19 identified in this study. The epidemiological data were integrated with the results from the phylogenetic tree and from the nucleotide-signature pattern Results The topologies of phylogenetic trees generated by the new and the conventional strategies were similar, with the former having better robustness than the latter, especially in comparison with the maximum-likelihood trees: the new strategy revealed that during 2003 there were 5 waves of epidemic SARS-CoV infection, which belonged to 3 phylogenetic clusters in Taiwan Conclusions The new strategy is more efficient than its conventional counterparts. The outbreaks of SARS in Taiwan originated from multiple sources
has issue date	2005-05-01(xsd:dateTime)
bibo:doi	10.1086/428591
bibo:pmid	15809907
has license	no-cc
sha1sum (hex)	c7be56777db84411888101b6d6b330dac408fd28
schema:url	https://doi.org/10.1086/428591
resource representing a document's title	Molecular Epidemiology of Severe Acute Respiratory Syndrome–Associated Coronavirus Infections in Taiwan
has PubMed Central identifier	PMC7199491
has PubMed identifier	15809907
schema:publication	J Infect Dis
resource representing a document's body	covid:c7be56777db84411888101b6d6b330dac408fd28#body_text
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