About: Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study

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About: Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study
Creator	Jang, Hee-Chang Kim, Seong Yeon, Ji
source	Medline; PMC
abstract	BACKGROUND: This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in standard nasopharyngeal/oropharyngeal (NP/OP) swabs. METHODS: Fifteen patients with SARS-CoV-2 infection from four hospitals were prospectively enrolled and matched samples of nasopharyngeal/oropharyngeal swabs and saliva were collected at Day 1 of admission and every other day till consequently negative for two times. Real-time reverse transcription polymerase chain reaction (rRT-PCR) was performed to detect the envelope (E) and RNA-dependent RNA polymerase (RdRP) genes. RESULTS: The cycle threshold values of saliva were comparable to those of NP/OP swabs overall (P = 0.720, Mann–Whitney U test). However, the overall sensitivity of rRT-PCR using saliva was 64% (34/53), which is lower than the 77% (41/53) using NP/OP swabs. The sensitivity of rRT-PCR using saliva was especially lower in early stage of symptom onset (1–5 days; 8/15; 53%) and in patients who did not have sputum (12/22; 55%). CONCLUSION: Saliva sample itself is not appropriate for initial diagnosis of coronavirus disease 2019 (COVID-19) to replace NP/OP swabs, especially for the person who does not produce sputum. COVID-19 cannot be excluded when the test using saliva is negative, and it is necessary to retest using NP/OP swabs.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.3346/jkms.2020.35.e287
bibo:pmid	32776725
has license	cc-by-nc
sha1sum (hex)	c7dd9e6d51e8158eb70c533bea799406c966c95a
schema:url	https://doi.org/10.3346/jkms.2020.35.e287
resource representing a document's title	Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study
has PubMed Central identifier	PMC7415999
has PubMed identifier	32776725
schema:publication	J Korean Med Sci
resource representing a document's body	covid:c7dd9e6d51e8158eb70c533bea799406c966c95a#body_text
is schema:about of	named entity 'days' named entity 'patients' named entity 'oropharyngeal' named entity 'HAVE' named entity 'SENSITIVITY' named entity 'ENROLLED' named entity 'envelope' named entity 'collected' named entity 'swabs' named entity 'kinetics' named entity 'Fifteen' named entity 'oropharyngeal' named entity 'saliva' named entity 'RdRP' named entity 'values' named entity 'viral load' named entity 'oropharyngeal' named entity 'rRT-PCR' named entity 'saliva' named entity 'sputum' named entity 'SARS-CoV-2' named entity 'CNU' named entity 'Korea' named entity 'saliva' named entity 'infection' named entity 'rRT-PCR' named entity 'saliva' named entity 'statistically significant' named entity 'Hwasun' named entity 'sputum' named entity 'viral load' named entity 'RNA' named entity 'saliva' named entity 'viral load' named entity 'symptom' named entity 'secretion' named entity 'saliva' named entity 'SARS-CoV-2' named entity 'Chonnam National University' named entity 'sputum' named entity 'interquartile range' named entity 'infection' named entity 'rRT-PCR' named entity 'HCW' named entity 'Informed consent' named entity 'cough' named entity 'RdRP' named entity 'LG Chem' named entity 'screening test' named entity 'SARS-CoV-2' named entity 'saliva' named entity 'saliva' named entity 'sputum' named entity 'Viral load' named entity 'peer reviewed' named entity 'pharyngeal' named entity 'rRT-PCR' named entity 'Kruskal-Wallis test' named entity 'oxygen therapy' named entity 'saliva' named entity 'IRB' named entity 'sputum' named entity 'saliva' named entity 'pharyngeal' named entity 'COVID' named entity 'RNA' named entity 'rRT-PCR' named entity 'CNU' named entity 'saliva samples' named entity 'SARS-CoV-2' named entity 'reverse transcription polymerase chain reaction' named entity 'Saliva samples' named entity 'infection' named entity 'viral load' named entity 'saliva' named entity 'RdRP' named entity 'COVID' named entity 'sputum' named entity 'FDA'

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