About: Vaccination of racing greyhounds: effects on humoral and cellular immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccination of racing greyhounds: effects on humoral and cellular immunity
Creator	Briggs, D Jordan ', F Mcmillen, G Mcvey, D Phillips, R
Source	Elsevier; Medline; PMC
abstract	Abstract Greyhound kennel owners frequently employ multiple vaccination schedules in an attempt to reduce financial losses incurred as a result of infectious diseases. In order to determine the effects of multiple vaccination schedules on the immune system of racing greyhounds, three litters of greyhound pups raised in laboratory conditions were divided into two groups and subjected to either a maximum or a minimum vaccination schedule. Blood samples were collected biweekly for 6 months beginning at 2 weeks of age and analyzed to establish ‘baseline’ values for the lymphatic system of greyhounds. Lymphocyte transformation, total and differential leukocyte counts, and flow cytometry were used to evaluate cellular immunity. Humoral immunity was evaluated using serum neutralization and hemagglutination inhibition tests. Proliferation of peripheral blood lymphocytes in response to the mitogen concanavalin A (Con A) was higher for the maximum vaccination groups. The frequency distribution of circulating CD4 and IgG labeled lymphocytes was higher in the minimum vaccination groups. A significant treatment by time interaction in CD4, IgG, and IgM labeled cells was observed. This interaction, however, was not significant at any point in time for CD4 and IgG labeled cells. The percentage of lymphocytes expressing surface IgM was significantly higher in the minimum vaccination groups at 10 and 14 weeks of age. No significant differences were detected in humoral immunity between the maximum and minimum groups of each litter. Results of this study indicate that maximum vaccination schedules do not appear to be more effective or more immunosuppressive than minimum vaccination schedules.
has issue date	1995-11-30(xsd:dateTime)
bibo:doi	10.1016/0165-2427(95)05446-d
bibo:pmid	8588333
has license	els-covid
sha1sum (hex)	c7de63b5da342deec06b42634a61bae605e01fe9
schema:url	https://doi.org/10.1016/0165-2427%2895%2905446-d
resource representing a document's title	Vaccination of racing greyhounds: effects on humoral and cellular immunity
has PubMed Central identifier	PMC7119874
has PubMed identifier	8588333
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:c7de63b5da342deec06b42634a61bae605e01fe9#body_text
is schema:about of	named entity 'author' named entity 'Elsevier Science' named entity 'immune system' named entity 'CONDITIONS' named entity '28913' named entity 'MINIMUM' named entity 'GREYHOUND' named entity 'TEL' named entity 'RAISED' named entity 'EMPLOY' named entity 'DIVIDED' named entity 'FAX' named entity 'MULTIPLE' named entity 'LABORATORY' named entity '2427' named entity 'TO REDUCE' named entity 'RIGHTS' named entity 'OWNERS' named entity 'BLOOD SAMPLES' named entity 'VACCINATION' named entity 'RACING' named entity 'GROUPS' named entity 'INFECTIOUS DISEASES' named entity 'FINANCIAL' named entity 'SCHEDULE' named entity 'BIWEEKLY' named entity 'EITHER' named entity '102' named entity 'VETERINARY IMMUNOLOGY' named entity 'PUPS' named entity 'FREQUENTLY' named entity 'SSDI' named entity 'EFFECTS' named entity 'VACCINATION' named entity 'AS A RESULT OF' named entity 'EFFECTS' named entity 'IMMUNE SYSTEM' named entity 'IMMUNOPATHOLOGY' named entity 'MAXIMUM' named entity 'ATTEMPT' named entity 'SCIENCE' named entity 'SCHEDULES' named entity 'DETERMINE' named entity 'RACING' named entity '101' named entity 'ORDER' named entity 'COLLECTED' named entity 'AUTHOR' named entity 'CELLULAR IMMUNITY' named entity 'raised' named entity 'Tel' named entity 'financial losses' named entity 'vaccination' named entity 'Immunopathology' named entity 'Vaccination' named entity 'humoral' named entity 'phenotyping' named entity '0.01' named entity 'vaccination' named entity 'antibody response' named entity 'antigen-antibody interactions' named entity 'lymphocytes' named entity 'PBMCs' named entity 'antibody' named entity 'IgG' named entity 'antibody' named entity 'mitogen' named entity 'serum' named entity 'vaccination' named entity 'phosphate-buffered saline' named entity 'host defense' named entity 'immunosuppression' named entity 'vaccination schedule' named entity 'antibody' named entity 'CDV' named entity 'vaccination' named entity 'antigenic'

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