About: Canine coronavirus infection in the dog following oronasal inoculation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Canine coronavirus infection in the dog following oronasal inoculation
Creator	Gaskell, R Tennant, B Carter, S Kelly, D
Source	Elsevier; Medline; PMC
abstract	Abstract The pathogenesis of canine coronavirus (CCV) infection in 10-week-old puppies was studied up to 14 days after oronasal inoculation. Mild diarrhoea was seen from three to 11 days after inoculation, approximately coincident with faecal virus shedding. Virus was initially isolated from the tonsils on day 3, and then from both small and large intestinal tissues up to 14 days after inoculation. Virus was also isolated from liver and lung. Histological changes were not seen in any tissues, but CCV antigen was detected, using a peroxidase antiperoxidase staining technique, mainly in epithelium overlying gut-associated lymphoid tissue. Virus neutralising antibody was first detected on day 10. Specific anti-CCV IgM was first detected in plasma three days after inoculation and IgG on days 4 to 7. Small amounts of anti-CCV IgG, IgM and IgA were detected in duodenal secretion, but none in bile.
has issue date	1991-07-31(xsd:dateTime)
bibo:doi	10.1016/0034-5288(91)90023-h
bibo:pmid	1654584
has license	els-covid
sha1sum (hex)	c7fffb9778776a7fc88144c264b6111927dea03f
schema:url	https://doi.org/10.1016/0034-5288%2891%2990023-h
resource representing a document's title	Canine coronavirus infection in the dog following oronasal inoculation
has PubMed Central identifier	PMC7131111
has PubMed identifier	1654584
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:c7fffb9778776a7fc88144c264b6111927dea03f#body_text
is schema:about of	named entity 'CORONAVIRUS INFECTION' named entity 'inoculation' named entity 'INOCULATION' named entity 'CANINE CORONAVIRUS' named entity 'FOLLOWING' named entity 'DOG' named entity 'dog' named entity 'diarrhoea' named entity 'infection' named entity 'sucrose' named entity 'EDTA' named entity 'polyvinylpyrrolidone' named entity 'adsorption' named entity 'Binn' named entity 'inoculation' named entity 'enteritis' named entity 'IgM' named entity 'inoculation' named entity 'immunoglobulins' named entity 'PBS' named entity 'immunocytochemical' named entity 'absorbance' named entity 'canine coronavirus' named entity 'Plasma' named entity 'transmissible gastroenteritis virus' named entity 'pathogenesis' named entity '37°C' named entity 'neonatal' named entity 'polyethylene glycol' named entity 'histology' named entity 'histological' named entity 'w/v' named entity 'coronavirus infections' named entity 'meninges' named entity 'meningitis' named entity 'virus' named entity 'adsorbing' named entity 'centrifugation' named entity 'IgG' named entity 'bile' named entity 'supernatants' named entity 'virus' named entity 'signs of disease' named entity 'plasma' named entity 'euthanasia' named entity 'infection' named entity 'lung' named entity 'infection' named entity 'growth medium' named entity 'coronaviruses' named entity 'infection' named entity 'virus' named entity 'virus' named entity 'lumen' named entity 'virus isolation' named entity 'duodenal' named entity 'IgG' named entity 'microtitre plate' named entity 'dog' named entity 'red blood cells' named entity 'oropharyngeal' named entity 'tissue culture' named entity 'infection' named entity 'epithelium' named entity 'transmissible gastroenteritis virus' named entity 'enterocytes' named entity 'histopathological' named entity 'IgA' named entity 'faecal samples' named entity 'infection' named entity 'enterocytes' named entity 'cell-mediated immunity' named entity 'neonatal' named entity 'Virus' named entity 'phosphate buffered saline' named entity 'virus' named entity 'dog' named entity 'post mortem examination'

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