About: Early T cell response in the central nervous system in canine distemper virus infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Early T cell response in the central nervous system in canine distemper virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early T cell response in the central nervous system in canine distemper virus infection
Creator	Moore, P Barben, · Burgener, · Moore, · Tipold, A Vandevelde, · Zurbriggen, ·
Source	Medline; PMC
abstract	The initial demyelinating lesions in canine distemper virus (CDV) infection develop during a period of severe immunosuppression in the absence of inflammation. In vitro and in vivo studies suggest that early demyelination is due to directly virus-induced oligodendroglial changes. In the present spatiotemporal study in experimentally CDV-infected dogs we observed diffuse up-regulation of T cells throughout the central nervous system (CNS) and T cell invasion in early demyelinating lesions. Invasion of T cells in the CNS occurred despite severe immunosuppression and without any perivascular cuffing. However, the major fraction of invading T cells correlated with sites of viral replication and coincided with the demonstration of an early immune response against the nucleocapsid protein of CDV. Activation of microglial cells was thought to have elicited the migration of T cells to the CNS by secretion of chemokines: marked IL-8 activity was found in the CSF of dogs with acute lesions. In areas of early demyelination, large numbers of CD3(+) cells accumulated in the tissue in the absence of any morphological sign of inflammation. Whether the T cells at lesion sites contribute to the development of acute demyelination remains uncertain at this stage. Antiviral cytotoxicity was not apparent since viral clearance in demyelinating lesions is only effective when B cells and concurring antiviral antibody production appeared in the subacute and chronic inflammatory stage of the disease. CD3(+) cells appear to persist for several weeks after infection since they were also found in recovered dogs that did not develop demyelination. Accumulation of immune cells, including a significant proportion of resting T cells (CD45RA(+)) in the CNS in the early stages of the disease may facilitate the later development of the intrathecal immune response and associated immunopathological complications.
has issue date	1999-01-01(xsd:dateTime)
bibo:doi	10.1007/s004010050954
bibo:pmid	9930894
has license	no-cc
sha1sum (hex)	c84e7ee1a29558045ec9f608216b468fc1607af0
schema:url	https://doi.org/10.1007/s004010050954
resource representing a document's title	Early T cell response in the central nervous system in canine distemper virus infection
has PubMed Central identifier	PMC7086574
has PubMed identifier	9930894
schema:publication	Acta Neuropathol
resource representing a document's body	covid:c84e7ee1a29558045ec9f608216b468fc1607af0#body_text
is schema:about of	named entity 'protein' named entity 'diffuse' named entity 'studies' named entity 'demyelination' named entity 'CNS' named entity 'nucleocapsid' named entity 'B cells' named entity 'Invasion' named entity 'PERIVASCULAR' named entity 'INFECTION' named entity 'IMMUNE CELLS' named entity 'SITES' named entity 'CELLS' named entity 'NUCLEOCAPSID PROTEIN' named entity 'LESIONS' named entity 'STAGE' named entity 'CANINE DISTEMPER VIRUS' named entity 'SUBACUTE' named entity 'DEMYELINATION' named entity 'PAPER' named entity 'REGULAR' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'initial' named entity 'chemokines' named entity 'immune cells' named entity 'chronic' named entity 'T cells' named entity 'experimentally' named entity 'However' named entity 'In vitro' named entity 'concurring' named entity 'CDV' named entity 'immunosuppression' named entity 'immune response' named entity 'T cell' named entity 'disease' named entity 'sign' named entity 'migration' named entity 'marked' named entity 'response' named entity 'lesion sites' named entity 'subacute' named entity 'inflammation' named entity 'cytotoxicity' named entity 'inflammation' named entity 'CNS' named entity 'intrathecal' named entity 'perivascular' named entity 'immunosuppression' named entity 'Antiviral' named entity 'antibody' named entity 'infection' named entity 'demyelination' named entity 'microglia' named entity 'astrocytes' named entity 'cytotoxic T lymphocytes' named entity 'lymphocytes' named entity 'rabies' named entity 'neutralizing antibodies' named entity 'CD3' named entity 'antibody response' named entity 'phosphate' named entity 'perivascular' named entity 'CDV' named entity 'CDV' named entity 'mAb' named entity 'demyelination' named entity 'chemotactic' named entity 'CD3' named entity 'rat' named entity 'cytokines' named entity 'IgG' named entity 'CDV' named entity 'cerebellum' named entity 'mAb'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software