About: Variable responses of formyl peptide receptor haplotypes toward bacterial peptides

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About: Variable responses of formyl peptide receptor haplotypes toward bacterial peptides Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
Creator	Mills, John Gripentrog, Jeannie Miettinen, Heini Saari, George
source	Medline; PMC
abstract	The chemoattractant neutrophil formyl peptide receptor (FPR) binds bacterial and mitochondrial N-formylated peptides, which allows the neutrophils to find the bacterial source and/or site of tissue damage. Certain inflammatory disorders may be due in part to an impaired innate immune system that does not respond to acute bacterial damage in a timely fashion. Because the human FPR is encoded by a large number of different haplotypes arising from ten single-nucleotide polymorphisms, we examined the possibility that some of these haplotypes are functionally distinct. We analyzed the response of three common FPR haplotypes to peptides from Escherichia coli, Mycobacterium avium ssp. paratuberculosis, and human mitochondria. All three haplotypes responded similarly to the E. coli and mitochondrial peptides, whereas one required a higher concentration of the M. avium peptide fMFEDAVAWF for receptor downregulation, receptor signaling, and chemotaxis. This raises the possibility of additional bacterial species differences in functional responses among FPR variants and establishes a precedent with potentially important implications for our innate immune response against bacterial infections. We also investigated whether certain FPR haplotypes are associated with rheumatoid arthritis (RA) by sequencing FPR1 from 148 Caucasian individuals. The results suggested that FPR haplotypes do not significantly contribute toward RA.
has issue date	2008-02-06(xsd:dateTime)
bibo:doi	10.1007/s00251-008-0277-3
bibo:pmid	18253729
has license	no-cc
sha1sum (hex)	c8581a31f67dbd6d888fe28abaa0bb0b243658a3
schema:url	https://doi.org/10.1007/s00251-008-0277-3
resource representing a document's title	Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
has PubMed Central identifier	PMC2435592
has PubMed identifier	18253729
schema:publication	Immunogenetics
resource representing a document's body	covid:c8581a31f67dbd6d888fe28abaa0bb0b243658a3#body_text
is schema:about of	named entity 'peptides' named entity 'inflammatory disorders' named entity 'fashion' named entity 'possibility' named entity 'VARIABLE' named entity 'ACUTE' named entity 'BACTERIAL' named entity 'ADDITIONAL' named entity 'HUMAN' named entity 'ESCHERICHIA COLI' named entity 'SEQUENCING' named entity 'CAUCASIAN' named entity 'ANALYZED' named entity 'PEPTIDE' named entity 'CONCENTRATION OF' named entity 'RESPOND TO' named entity 'EXAMINED' named entity 'MAY BE' named entity 'THESE' named entity 'NEUTROPHILS' covid:arg/c8581a31f67dbd6d888fe28abaa0bb0b243658a3 named entity 'IMPORTANT' named entity 'DISORDERS' named entity 'INDIVIDUALS' named entity 'CHEMOTAXIS' named entity 'CONTRIBUTE ' named entity 'VARIANTS' named entity 'FPR1' named entity 'DO NOT' named entity 'INFLAMMATORY' named entity 'NUMBER OF' named entity 'RESULTS' named entity 'DOWNREGULATION' named entity 'MITOCHONDRIA' named entity 'COMMON' named entity '148' named entity 'BINDS' named entity 'PEPTIDES' named entity 'FASHION' named entity 'IMPAIRED' named entity 'PEPTIDES' named entity 'BACTERIAL INFECTIONS' named entity 'INNATE IMMUNE RESPONSE' named entity 'SPECIES DIFFERENCES' named entity 'REQUIRED' named entity 'DISTINCT' named entity 'FPR' named entity 'NEUTROPHIL' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISMS' named entity 'INVESTIGATED' named entity 'ARISING' named entity 'ASSOCIATED WITH' named entity 'RESPONSES' named entity 'FUNCTIONAL' named entity 'MITOCHONDRIAL' named entity 'HIGHER' named entity 'PRECEDENT' named entity 'RECEPTOR SIGNALING' named entity 'LARGE' named entity 'DIFFERENT' named entity 'RHEUMATOID ARTHRITIS' named entity 'RESPONSE' named entity 'BACTERIAL' named entity 'RESPONSES' named entity 'INNATE IMMUNE SYSTEM' named entity 'DAMAGE' named entity 'SITE OF' named entity 'OUR' named entity 'SOURCE' named entity 'TIMELY' named entity 'RECEPTOR' named entity 'CERTAIN' named entity 'ENCODED' named entity 'TISSUE DAMAGE' named entity 'ALLOWS' named entity 'POSSIBILITY' named entity 'CHEMOATTRACTANT' named entity 'E. COLI'

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