About: Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017
Creator	Amer, Hala Assiri, Abdullah Lu, Xiaoyan Li, Yan Watson, John Al-Abdely, Hail Abdalla, Osman Hakawi, Ahmed Trivedi, Suvang Biggs, Holly Killerby, Marie Alhakeem, Raafat Sakthivel, Senthilkumar Alanazi, Khalid Gerber, Susan Alsharef, Ali Bereagesh, Samar Mbbs, Alfalah, Haitham Almari, Aref Alresheedi, Husain Abedi Mph, Glen Killerby Vetmb, Marie Mbbs, Hani Mutaz, Mohammed Paden Phd, Clinton Queen Phd, Krista Tamin Phd, Azaibi Tao Phd, Ying Tawfik, Sameh Thornburg Phd, Natalie Tong Phd, Suxiang Zhang Phd, Jing
Source	Medline; PMC
abstract	OBJECTIVE: To investigate a Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak event involving multiple healthcare facilities in Riyadh, Saudi Arabia; to characterize transmission; and to explore infection control implications. DESIGN: Outbreak investigation. SETTING: Cases presented in 4 healthcare facilities in Riyadh, Saudi Arabia: a tertiary-care hospital, a specialty pulmonary hospital, an outpatient clinic, and an outpatient dialysis unit. METHODS: Contact tracing and testing were performed following reports of cases at 2 hospitals. Laboratory results were confirmed by real-time reverse transcription polymerase chain reaction (rRT-PCR) and/or genome sequencing. We assessed exposures and determined seropositivity among available healthcare personnel (HCP) cases and HCP contacts of cases. RESULTS: In total, 48 cases were identified, involving patients, HCP, and family members across 2 hospitals, an outpatient clinic, and a dialysis clinic. At each hospital, transmission was linked to a unique index case. Moreover, 4 cases were associated with superspreading events (any interaction where a case patient transmitted to ≥5 subsequent case patients). All 4 of these patients were severely ill, were initially not recognized as MERS-CoV cases, and subsequently died. Genomic sequences clustered separately, suggesting 2 distinct outbreaks. Overall, 4 (24%) of 17 HCP cases and 3 (3%) of 114 HCP contacts of cases were seropositive. CONCLUSIONS: We describe 2 distinct healthcare-associated outbreaks, each initiated by a unique index case and characterized by multiple superspreading events. Delays in recognition and in subsequent implementation of control measures contributed to secondary transmission. Prompt contact tracing, repeated testing, HCP furloughing, and implementation of recommended transmission-based precautions for suspected cases ultimately halted transmission.
has issue date	2018-12-31(xsd:dateTime)
bibo:doi	10.1017/ice.2018.290
bibo:pmid	30595141
has license	no-cc
sha1sum (hex)	c879f96dc666478293b40f9308abb1ab03d87e3c
schema:url	https://doi.org/10.1017/ice.2018.290
resource representing a document's title	Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017
has PubMed Central identifier	PMC7108661
has PubMed identifier	30595141
schema:publication	Infect Control Hosp Epidemiol
resource representing a document's body	covid:c879f96dc666478293b40f9308abb1ab03d87e3c#body_text
is schema:about of	named entity 'cases' named entity 'infection control' named entity 'cases' named entity 'patients' named entity 'healthcare' named entity 'control' named entity 'HCP' named entity 'patients' named entity 'transmitted' named entity 'separately' named entity 'case' named entity 'unique' named entity 'family' named entity '2017' named entity 'RIYADH' named entity 'PERFORMED' named entity 'INFECTION CONTROL' named entity 'EXPOSURES' named entity 'INITIALLY' named entity 'DIALYSIS' named entity 'AVAILABLE' named entity 'ASSOCIATED' named entity 'CASES' named entity 'IMPLEMENTATION' named entity 'INTERACTION' named entity 'SECONDARY TRANSMISSION' named entity 'CASE' named entity 'SUBSEQUENT' named entity 'PERSONNEL' named entity 'A55' named entity 'HCP' named entity 'PCR' named entity 'ASSESSED' named entity 'GENOME SEQUENCING' named entity 'SEROPOSITIVE' named entity 'SEVERELY' named entity 'INVESTIGATION' named entity 'OUTBREAK' named entity 'ACROSS' named entity 'SEROPOSITIVITY' named entity 'HEALTHCARE FACILITIES' named entity 'TOTAL' named entity 'SPECIALTY' named entity 'HEALTHCARE' named entity 'CONTACTS' named entity 'DIED' named entity 'OUTPATIENT CLINIC' named entity 'PRESENTED' named entity '283'

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