About: Engineering self-assembled materials to study and direct immune function

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Engineering self-assembled materials to study and direct immune function
Creator	Jewell, Christopher Tostanoski, Lisa
Source	Elsevier; Medline; PMC
abstract	Abstract The immune system is an awe-inspiring control structure that maintains a delicate and constantly changing balance between pro-immune functions that fight infection and cancer, regulatory or suppressive functions involved in immune tolerance, and homeostatic resting states. These activities are determined by integrating signals in space and time; thus, improving control over the densities, combinations, and durations with which immune signals are delivered is a central goal to better combat infectious disease, cancer, and autoimmunity. Self-assembly presents a unique opportunity to synthesize materials with well-defined compositions and controlled physical arrangement of molecular building blocks. This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues. We present work centered on fundamental properties that regulate the nature and magnitude of immune response, highlight pre-clinical and clinical applications of self-assembled technologies in vaccines, cancer, and autoimmunity, and describe some of the key manufacturing and regulatory hurdles facing these areas.
has issue date	2017-05-15(xsd:dateTime)
bibo:doi	10.1016/j.addr.2017.03.005
bibo:pmid	28392305
has license	els-covid
sha1sum (hex)	c89186e7b4d0b8533280c31a29b87d931c1e8d06
schema:url	https://doi.org/10.1016/j.addr.2017.03.005
resource representing a document's title	Engineering self-assembled materials to study and direct immune function
has PubMed Central identifier	PMC6262758
has PubMed identifier	28392305
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:c89186e7b4d0b8533280c31a29b87d931c1e8d06#body_text
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