About: Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study

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About: Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study
Creator	Andersen, Ove Eugen-Olsen, Jesper Kofoed, Kristian Kronborg, Gitte Larsen, Klaus Petersen, Janne Tvede, Michael
Source	Medline; PMC
abstract	INTRODUCTION: Accurate and timely diagnosis of community-acquired bacterial infections in patients with systemic inflammation remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination. METHODS: This prospective cohort study included patients with systemic inflammatory response syndrome who were suspected of having community-acquired infections. It was conducted in a medical emergency department and department of infectious diseases at a university hospital. A multiplex immunoassay measuring soluble urokinase-type plasminogen activator (suPAR) and soluble triggering receptor expressed on myeloid cells (sTREM)-1 and macrophage migration inhibitory factor (MIF) was used in parallel with standard measurements of C-reactive protein (CRP), procalcitonin (PCT), and neutrophils. Two composite markers were constructed – one including a linear combination of the three best performing markers and another including all six – and the area under the receiver operating characteristic curve (AUC) was used to compare their performance and those of the individual markers. RESULTS: A total of 151 patients were eligible for analysis. Of these, 96 had bacterial infections. The AUCs for detection of a bacterial cause of inflammation were 0.50 (95% confidence interval [CI] 0.40 to 0.60) for suPAR, 0.61 (95% CI 0.52 to 0.71) for sTREM-1, 0.63 (95% CI 0.53 to 0.72) for MIF, 0.72 (95% CI 0.63 to 0.79) for PCT, 0.74 (95% CI 0.66 to 0.81) for neutrophil count, 0.81 (95% CI 0.73 to 0.86) for CRP, 0.84 (95% CI 0.71 to 0.91) for the composite three-marker test, and 0.88 (95% CI 0.81 to 0.92) for the composite six-marker test. The AUC of the six-marker test was significantly greater than that of the single markers. CONCLUSION: Combining information from several markers improves diagnostic accuracy in detecting bacterial versus nonbacterial causes of inflammation. Measurements of suPAR, sTREM-1 and MIF had limited value as single markers, whereas PCT and CRP exhibited acceptable diagnostic characteristics. TRIAL REGISTRATION: NCT 00389337
has issue date	2007-03-16(xsd:dateTime)
bibo:doi	10.1186/cc5723
bibo:pmid	17362525
has license	cc-by
sha1sum (hex)	c899a0907dc026208ece3df9c6d4b3c909c6dd46
schema:url	https://doi.org/10.1186/cc5723
resource representing a document's title	Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study
has PubMed Central identifier	PMC2206456
has PubMed identifier	17362525
schema:publication	Crit Care
resource representing a document's body	covid:c899a0907dc026208ece3df9c6d4b3c909c6dd46#body_text
is schema:about of	named entity 'CLINICIAN' named entity 'ONES' named entity 'BACTERIAL INFECTIONS' named entity 'MARKERS' named entity 'SEPSIS' named entity 'COMBINATION' named entity 'LABORATORY' named entity 'compared' named entity 'diagnosis' named entity 'remains' named entity 'timely' named entity 'Combinations' named entity 'combination' named entity 'COMBINATION' named entity 'MACROPHAGE MIGRATION INHIBITORY FACTOR' named entity 'DIAGNOSTIC' named entity 'COMPARED' named entity 'INTRODUCTION' named entity 'ACCURATE' named entity 'USED' named entity 'TIMELY' named entity 'PLASMA' named entity 'C-REACTIVE PROTEIN' named entity 'ACCESS' named entity 'SOLUBLE' named entity 'PROSPECTIVE STUDY' named entity 'UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR' named entity 'TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1' named entity 'DIAGNOSE' named entity 'PROCALCITONIN' named entity 'NEUTROPHILS' named entity 'INFECTIONS' named entity 'OPEN' named entity 'USE OF' named entity 'SINGLE' named entity 'SURVIVAL' named entity 'BIOMARKERS' named entity 'SYSTEMIC INFLAMMATION' named entity 'NOVEL' named entity 'PATIENTS' named entity 'CHARACTERISTICS' named entity 'DIAGNOSIS' named entity 'COMBINATIONS' covid:arg/c899a0907dc026208ece3df9c6d4b3c909c6dd46 named entity 'laboratory' named entity 'soluble' named entity 'Open Access' named entity 'myeloid cells' named entity 'plasma' named entity 'bacterial infections' named entity 'prospective study' named entity 'receptor' named entity 'REMAINS' named entity 'procalcitonin' named entity 'soluble urokinase-type plasminogen activator receptor' named entity 'biomarkers' named entity 'sepsis' named entity 'clinician' named entity 'systemic inflammation' named entity 'C-reactive protein' named entity 'macrophage migration inhibitory factor' named entity 'neutrophils' named entity 'Accurate' named entity 'opposed' named entity 'improve' named entity 'systemic inflammation' named entity 'combination' named entity 'prospective study' named entity 'biomarkers' named entity 'sepsis' named entity 'expressed' named entity 'procalcitonin' named entity 'infections' named entity 'diagnosis' named entity 'survival'

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