About: Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy
Creator	Cooper, David Brzezinski, Dariusz Chruszcz, Maksymilian Czub, Mateusz Grabowski, Marek Majorek, Karolina Minor, Wladek Panasiuk, Mateusz Shabalin, Ivan
Source	BioRxiv; Medline; PMC
abstract	Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Herein, we report the first structure of serum albumin in complex with dexamethasone. We show that it binds to Drug Site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with our analysis of publicly available clinical data from Wuhan and suggests that an adjustment of dexamethasone regimen should be considered for patients affected by two major COVID-19 risk-factors: low albumin levels and diabetes.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.212704
bibo:pmid	32743572
has license	cc-by
sha1sum (hex)	c8b27d9ca91b074be726a29d885f0a648acc43c1
schema:url	https://doi.org/10.1101/2020.07.21.212704
resource representing a document's title	Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy
has PubMed Central identifier	PMC7386489
has PubMed identifier	32743572
schema:publication	bioRxiv
resource representing a document's body	covid:c8b27d9ca91b074be726a29d885f0a648acc43c1#body_text
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