About: X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy

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About: X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy
Creator	Campos, Rodolfo Barbini, Luciana Mercedes Elizalde, María
Source	Elsevier; Medline; PMC
abstract	Abstract The hepatitis B virus X protein (HBV-X) is a multifunctional regulatory protein associated with the pathogenesis of liver disease in chronic HBV infection. Basal core promoter mutations (BCP), associated with the clinical course of chronic HBV infection, affect HBV-X at 130–131 positions. The role of these mutations on HBV-X biological activity remains largely unknown. The aim of this study was to analyze the impact of the presence of different amino acids at 130–131 positions of HBV-X on the biological activity of the protein. Transient expression of wild type and mutant F1b and F4 HBV-X increased cell mortality by the induction of apoptosis in human hepatoma cells. The wild type and mutant HBV-X differentially modulate the expression of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2 and Bcl-X) regulatory proteins of the Bcl-2 family. Furthermore, the expression of HBV-X variants of both subgenotypes induced autophagy of human tumoral hepatocytes. In conclusion, HBV-X variants of the Latin American HBV F genotype promotes human hepatocytes death by the induction of apoptosis and autophagy. The results of this work describe some of the molecular mechanisms by which HBV-X variants contribute to the pathogenesis of liver diseases in the infected liver and help to the biological characterization of genotype F, responsible of the majority of HBV infections in Argentina.
has issue date	2017-10-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2017.09.025
bibo:pmid	28986109
has license	els-covid
sha1sum (hex)	c8e925c81013813f986199679a738341c9a02b82
schema:url	https://doi.org/10.1016/j.virusres.2017.09.025
resource representing a document's title	X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy
has PubMed Central identifier	PMC7114566
has PubMed identifier	28986109
schema:publication	Virus Research
resource representing a document's body	covid:c8e925c81013813f986199679a738341c9a02b82#body_text
is schema:about of	named entity 'hepatocytes' named entity 'HEPATITIS B VIRUS X PROTEIN' named entity 'HBV INFECTION' named entity 'IS A' named entity 'HBV' named entity 'THESE' named entity 'PATHOGENESIS' named entity 'AUTOPHAGY' named entity 'RESPONSIBLE' named entity 'MAJORITY' named entity 'HEPATOCYTES' named entity 'HELP' named entity 'AFFECT' named entity 'PRO-' named entity 'F1B' named entity 'AMINO ACIDS' named entity 'LIVER' named entity 'ASSOCIATED WITH' named entity 'TRANSIENT EXPRESSION' named entity 'LARGELY' named entity 'DIFFERENT' named entity 'BCL-2 FAMILY' named entity 'CELL' named entity 'DEATH' named entity 'PRESENCE OF' named entity 'MUTATIONS' named entity 'INDUCED' named entity 'CONTRIBUTE ' named entity 'BCL-X' named entity 'INDUCTION OF APOPTOSIS' named entity 'PROTEIN ' named entity 'CHRONIC' named entity 'WILD TYPE' named entity 'ROLE' named entity 'INFECTED' named entity 'INFECTIONS' named entity 'OF LIVER DISEASE' named entity 'MUTANT' named entity 'CLINICAL COURSE' named entity 'REGULATORY PROTEIN' named entity 'STUDY' named entity 'MORTALITY' named entity 'CONCLUSION' named entity 'CORE PROMOTER' named entity 'PROTEIN' named entity 'ARGENTINA' named entity 'HEPATOMA CELLS' named entity 'WORK' named entity 'REGULATORY PROTEINS' named entity 'RESULTS' named entity 'MECHANISMS' named entity 'GENOTYPE' named entity 'DESCRIBE' named entity 'LATIN AMERICAN' named entity 'AT 130' named entity 'UNKNOWN' named entity 'VARIANTS' named entity 'INCREASED' named entity 'HUMAN' named entity 'CHARACTERIZATION' named entity 'APOPTOTIC' named entity 'IMPACT' named entity 'AIM' named entity 'MODULATE' named entity 'BIOLOGICAL ACTIVITY' named entity 'MOLECULAR' named entity 'BASAL' named entity 'EXPRESSION' named entity 'BIOLOGICAL' named entity 'POSITIONS' covid:arg/c8e925c81013813f986199679a738341c9a02b82 named entity 'human' named entity 'infection' named entity 'mortality' named entity 'liver' named entity 'pathogenesis' named entity 'mutant' named entity 'chronic HBV' named entity 'genotype'

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