About: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

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About: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Creator	Akbari, Hamed Aria, Hamid Asadian, Fatemeh Faramarz, Sanaz Keshavarz, Pedram Lankarani, Kamran Noroozi, Saam Tabrizi, Reza Vakili, Sina
Source	Elsevier; Medline; PMC
abstract	AIMS: This study aimed to make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones. MATERIALS AND METHODS: Relevant studies were searched in PubMed, Embase, Scopus, and Web of Science databases until March 31, 2020. Cochrane's Q test and the I(2) statistic were used to determine heterogeneity. We used the random-effect models to pool the weighted mean differences (WMDs) and 95% confidence intervals (CIs). KEY FINDINGS: Out of a total of 8557 initial records, 44 articles (50 studies) with 7865 patients (ranging from 13 to 1582), were included. Our meta-analyses with random-effect models showed a significant decrease in lymphocytes, monocyte, CD4+ T cells, CD8+ T cells, CD3 cells, CD19 cells, and natural killer (NK) cells and an increase in the white blood cell (WBC), neutrophils, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP)/hs-CRP, erythrocyte sedimentation rate (ESR), ferritin, procalcitonin (PCT), and serum amyloid A (SAA), interleukin-2 (IL-2), IL-2R, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) in the severe group compared to the non-severe group. However, no significant differences were found in IL-1β, IL-17, and CD4/CD8 T cell ratio between the two groups. SIGNIFICANCE: Decrease in total lymphocytes and lymphocyte subsets as well as the elevation of CRP, ESR, SAA, PCT, ferritin, and cytokines, but not IL-1β and IL-17, were closely associated with COVID-19 severity, implying reliable indicators of severe COVID-19.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1016/j.lfs.2020.118167
bibo:pmid	32735885
has license	no-cc
sha1sum (hex)	c8f9844f4162833c8ff47092b16f89e52ee7cd4c
schema:url	https://doi.org/10.1016/j.lfs.2020.118167
resource representing a document's title	The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
has PubMed Central identifier	PMC7387997
has PubMed identifier	32735885
schema:publication	Life Sci
resource representing a document's body	covid:c8f9844f4162833c8ff47092b16f89e52ee7cd4c#body_text
is schema:about of	named entity 'Subsets' named entity 'Cytokine' named entity 'ORDER' named entity 'SEVERE' covid:arg/c8f9844f4162833c8ff47092b16f89e52ee7cd4c named entity 'This' named entity 'CBC' named entity 'clinical laboratory' named entity 'lymphocyte subsets' named entity 'complete blood count' named entity 'pneumonia' named entity 'cellular immune response' named entity 'proinflammatory' named entity 'CD8+ T cells' named entity 'gastrointestinal tract' named entity 'virus infections' named entity 'coronavirus' named entity 'pulmonary disease' named entity 'systematic review' named entity 'meta-analysis' named entity 'IL-4' named entity 'IL-10' named entity 'cytokines' named entity 'outcome measure' named entity 'IL-2' named entity 'IFN-γ' named entity 'clinical studies' named entity 'IL-2' named entity 'SARS' named entity 'cytokine' named entity 'Cochrane' named entity 'intensive care unit' named entity 'laboratory tests' named entity 'CD4+' named entity 'systemic disorder' named entity 'cytokines' named entity 'meta-analysis' named entity 'blood sample' named entity 'CD8+ T cells' named entity 'biomarker' named entity 'IL-17' named entity 'WMD' named entity 'sample size' named entity 'mechanical ventilation' named entity 'partial pressure' named entity 'pneumonia' named entity 'resting pulse' named entity 'ICU' named entity 'lesion' named entity 'COVID' named entity 'inflammatory responses' named entity 'infection' named entity 'Q test' named entity 'pathogen' named entity 'NK cells' named entity 'IL-10' named entity 'statistical analyses' named entity 'Microsoft excel' named entity 'FiO2' named entity 'chemokine' named entity 'cytokines' named entity 'organ' named entity 'COVID' named entity 'COVID' named entity 'lymphocytes' named entity 'confidence intervals' named entity 'lymphopenia' named entity 'sensitivity, and specificity' named entity 'CBC' named entity 'innate immune' named entity 'COVID' named entity 'WMD' named entity 'inflammatory response'

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